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A Double-Blinded, Placebo-controlled, Double Dummy, Multi-center Randomized, Phase 3 Study to Evaluate the Efficacy and Safety of ORMD-0801 in Subjects With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on One to Three Glucose-lowering Agents
ORA-013-3 is a randomized, controlled study to test the efficacy and safety of an oral capsule of ORMD-0801 at several doses in patients with Type 2 Diabetes M…
Comparative Effectiveness of Two Initial Combination Therapies in Patients With New Onset Diabetes
The primary purpose of this study is to evaluate the efficacy, durability, and mechanism of HbA1c reduction produced by the combination of pioglitazone plus ti…
Impact of Time-Restricted Eating (TRE) on Kidney Health (The TREK Study)
This is a clinical trial to assess how time-restricted eating (TRE) may improve kidney health and filtration patients with type 2 diabetes and increased protei…
Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction
The goal of this clinical trial is to examine the role of autophagy on microvascular function in adults with Type 2 Diabetes. The main question it aims to answ…
Vitamin D and Type 2 Diabetes, Treat-To-Target
This study tests whether taking a weekly dose of vitamin D, with the dose adjusted to reach a target blood vitamin D level, can help control blood sugar levels…
Leveraging the Exposome and Patient Sensor Data to Enhance Personalized Diabetes Care Across Diverse Communities
The study aims to integrate various data types, such as electronic health records, wearable device data, and environmental data, to create a comprehensive, per…
Protocol l: SGLT2 Inhibitors, Ketogenesis, and Ketoacidosis
In this study, we will test the hypothesis that distinct mechanisms account for the SGLT2i-induced stimulation of ketogenesis and lipolysis versus endogenous (…
HP-211 Safety and Proof of Concept Dose Ranging Study in Patients With Type 2 Diabetes
Blood sugar levels are controlled by insulin, a hormone made by cells in the pancreas. After a meal, carbohydrates are broken down into glucose which is absorb…
CGMs for All: Studying the Impact of Expanding CGM Access
This non-blinded, non-randomized pre-post study will examine the impact of providing CGM sensors free of charge to adult patients of Fair Haven Community Healt…
Effects of Acute and Chronic Ketone Ester Consumption on Exercise Tolerance and Cardiac Function in Subjects With Diabetes
This study is being done to evaluate how a ketone ester (KE) supplement affects heart function and health in people with diabetes compared to a placebo supplem…
Effect of Low-Dose Pioglitazone in Patients With Nonalcoholic Steatohepatitis (NASH)
To determine the safety and efficacy of low-dose pioglitazone (15 mg per day) on liver histology in in patients with T2DM with biopsy-proven nonalcoholic steat…
PANTHER Study: Puberty, Diabetes, and the Kidneys, When Eustress Becomes Distress
Early diabetic kidney disease (DKD) occurs in 50-70% of youth with type 2 diabetes (T2D) and confers high lifetime risk of dialysis and premature death. Youth-…