The purpose of this study is to find out if a drug called lurbinectedin (the "study drug") is safe and effective at treating people with recurrent or relapsed …

Ewing SarcomaDesmoplastic Small Round Cell TumorPediatric Cancer+1 more

~Estimated

~$10 – $6,250

Children's Hospital of PhiladelphiaNCT05918640

Phase 1

NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)

The study participant has been diagnosed with non-rhabdomyosarcoma (NRSTS). Primary Objectives Intermediate-Risk * To estimate the 3-year event-free surviva…

Adipocytic NeoplasmLiposarcomaAtypical Fibroxanthoma+39 more

Phase 1

Phase I Study of HER2 Chimeric Antigen Receptor (CAR) T Cells in Combination With Checkpoint Blockade in Patients With Advanced Sarcoma (HEROS 3.0)

The purpose of this study is to learn whether it is safe to give HER2-CAR T cells in combination with an immune checkpoint inhibitor drug (pembrolizumab or niv…

SarcomaHER-2 Protein OverexpressionOsteosarcoma+5 more

~Estimated

~$10 – $6,250

Baylor College of MedicineNCT04995003

~Estimated

~$10 – $6,250

St. Jude Children's Research HospitalNCT06239272