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Phase 2
A Double-Blind, Placebo-Controlled, Multicenter, Randomized Phase 2 Trial Evaluating the Efficacy and Safety of Felzartamab in Recipients of Kidney Transplants With Late Isolated Microvascular Inflammation (MVI)
In this study, researchers will learn more about a drug called felzartamab in people who have received a kidney transplant and later developed a condition call…
Microvascular Inflammation
BiogenNCT07219043
Observational
CaRi-Heart® Assessment of Risk and Evaluation of Inflammation in Coronary CT Angiography (CARE-CCTA): A Prospective U.S. Community-Based Study on the Impact of CaRi-Heart® Analysis in Patients Undergoing CCTA for Coronary Artery Disease
This study evaluates the use of CaRi-Heart® analysis, an artificial-intelligence (AI) software tool that measures inflammation in the coronary arteries using i…
Coronary Artery DiseaseAtherosclerosisCardiovascular Inflammation
Corazon Medical PCNCT07220304
Phase 4
The Effects of Soluble Guanylyl Cyclase Stimulation on Perioperative Vascular Reactivity and Organ Injury in Cardiac Surgery
The goal of this mechanistic clinical trial is to learn about the effects of medications called soluble guanylyl cyclase stimulators on vascular function and m…
Endothelial DysfunctionVascular DiseasesKidney Injury+2 more
Vanderbilt University Medical CenterNCT05812755
Phase 2
Effects of IL-1 Beta Inhibition on Vascular Inflammation in TET2 Clonal Hematopoiesis
The primary goal of this clinical trial is to test the hypothesis that the drug canakinumab (anti-IL-1B monoclonal antibody) decreases vascular inflammation wh…
Vascular InflammationASCVDASCVD Management
Massachusetts General HospitalNCT06691217