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Alpelisib Challenge Test (ACT) for Assessment of Pancreatic β-Cell Reserve, Pilot & Feasibility Study

The goal of this study is to test a potentially easier method for measuring how much insulin a person is capable of producing than the current gold-standard me…

Insulin ResistanceType 2 DiabetesObesity & Overweight+1 more

Estimated

~$10 – $6,250

Columbia UniversityNCT07778524

Phase 3

A Phase 3, Open-label, Randomized Study to Compare the Efficacy and Safety of Nemtabrutinib (MK-1026) Plus Venetoclax Versus Venetoclax Plus Rituximab in Participants With Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Following at Least 1 Prior Therapy (BELLWAVE-010)

The purpose of this study is to assess the safety and tolerability and to confirm the dose of nemtabrutinib in combination with venetoclax in participants with…

Leukemia, Lymphocytic, Chronic, B-CellLeukemia, Chronic LymphocyticSmall-Cell Lymphoma+3 more

Estimated

~$10 – $8,750

Merck Sharp & Dohme LLCNCT05947851

Amyloid PET Imaging in the Baltimore Longitudinal Study of Aging (BLSA)

Background: Some people experience cognitive decline as they age. That is, they lose memory, problem-solving, and other mental abilities. Amyloids are groups …

Aging

Estimated

~$10 – $675

National Institute on Aging (NIA)NCT07099053

Observational

Interventions in Math Learning Disabilities: Cognitive and Neural Correlates

The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing and remediating weaknesses in arit…

Math Learning DisabilityLearning DisabilitiesLearning Disabilities, Child+2 more

Estimated

~$10 – $6,250

Stanford UniversityNCT07778706

Phase 2

A Parallel-Group Treatment, Phase 2, Double-Blind Study of Once-Weekly Subcutaneous LY3457263 Compared to Placebo in Participants With Type 2 Diabetes Mellitus on a Stable Dose of Semaglutide or Tirzepatide Who Failed to Achieve HbA1c Goal

The purpose of this study is to measure the change in hemoglobin A1c (HbA1c) with LY3457263 compared with placebo in participants with type 2 diabetes who are …

Type 2 Diabetes

Estimated

~$10 – $7,500

Eli Lilly and CompanyNCT06897475

Observational

Effects of Dry Needling on Quadriceps Muscle Strength in Acute Post-Operative Anterior Cruciate Ligament Reconstruction With Quadriceps Autograft in the Pediatric Population

Dry needling is a skilled intervention provided by trained physical therapists to treat pain, myofascial dysfunction, and a variety of other diagnosis. While t…

Anterior Cruciate Ligament Reconstruction RehabilitationDry NeedlingStrength

Estimated

~$10 – $6,250

Children's Mercy Hospital Kansas CityNCT07657195

A Natural History of Cardiometabolic Disease Among US Bhutanese: Developing the Bhutanese Community of Central Ohio Health Study to Identify Synergizing Socioenvironmental and Biobehavioral Risk Factors Propagating Health Disparities From a Cross-Sectional Study

Background: As of 2021, almost 45 million people in the United States were foreign-born immigrants. South Asians, including people from Bhutan, are the fastes…

Cardiometabolic Risk FactorsMental Health

Estimated

~$10 – $675

National Institute of Environmental Health Sciences (NIEHS)NCT06991751

Phase 2

A Phase II Study of Combination Bevacizumab and PRGN-2012 in Adults With Recurrent Respiratory Papillomatosis (RRP)

Background: Recurrent respiratory papillomatosis (RRP) is a rare disease that causes wart-like growths called papillomas to grow in the airway, most often in …

Respiratory Recurrent Papillomatosis (RRP)Human Papillomavirus (HPV)Papillomavirus Infection+3 more

Estimated

~$10 – $5,625

National Cancer Institute (NCI)NCT07756840

Phase 1

An Open-label, First-in-Human, Single Ascending Dose Study of QUAIL-100 in Pediatric and Young Adult Subjects With High-Risk Acute Leukemias and Myelodysplastic Syndrome Who Have Received a T-cell Receptor (TCR) αβ+ T Cell/CD-19+ B Cell-Depleted Hematopoietic Stem Cell Transplantation

Study of QUAIL-100 in Patients With High Risk Acute Leukemia and Myelodysplastic Syndrome Who Have Received Hematopoietic Stem Cell Transplant

Acute LeukemiaMyelodysplastic Syndrome

Estimated

~$10 – $8,750

Laguna Biotherapeutics, Inc.NCT07573111

Phase 1

BAF_FRontier-1, A First-in-Human, Phase 1 Trial to Assess Safety, Tolerability, and Preliminary Efficacy of LY4152199, a B-cell Activation Factor Receptor (BAFF-R) T-Cell Engager Bispecific Antibody in Adult Participants With Previously Treated B-cell Malignancies

The purpose of this study is to find the best dose of the drug and measure the safety and efficacy of LY4152199 in participants with previously treated B-cell …

Lymphoma, Non-HodgkinB-cell LymphomaLymphoma, Large B-Cell, Diffuse+4 more

Estimated

~$10 – $7,500

Eli Lilly and CompanyNCT07101328

Phase 1

A Phase 1a/b Multicenter, Open-Label Trial to Evaluate Safety, Tolerability, and Dosimetry of LY4257496, a GRPR-Targeted Radioligand Therapy, in Adults With GRPR-Positive Advanced Solid Tumors (OMNIRAY)

The main purpose of this study is to evaluate safety, tolerability, and efficacy of LY4257496 alone and as part of relevant standard of care (SOC) combination …

Breast NeoplasmsColorectal NeoplasmsProstate Neoplasm+4 more

Estimated

~$10 – $7,500

Eli Lilly and CompanyNCT07114601

Phase 3

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Trial of Lepodisiran to Investigate the Effect on Coronary Plaque in Adults With Elevated Lp(a) Who Have Established Atherosclerotic Cardiovascular Disease or Are at Risk for a First Cardiovascular Event

Lipoprotein(a), also known as Lp(a), is a protein that carries cholesterol and proteins in your blood. People with high Lp(a) have a higher risk for heart dise…

AtherosclerosisCardiovascular DiseasesLipoprotein(a)

Estimated

~$10 – $7,500

Eli Lilly and CompanyNCT07613294