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A Randomized Pivotal Study Assessing the Safety and Efficacy of Targeted Blood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound During the Standard of Care Treatment of Brain Metastases of Non-small Cell Lung Cancer (NSCLC) Origin

The purpose of this study is to evaluate the safety and efficacy of targeted blood brain barrier opening with Exablate Model 4000 Type 2.0/2.1 for the treatmen…

Brain TumorNon Small Cell Lung Cancer

A Participant- and Investigator--Blinded, Placebo- Controlled, Randomized, Multipart, Single and Multiple Ascending Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of OJR520 in Healthy Volunteers and Participants With Chronic Kidney Disease

The purpose of this first-in-human (FIH) study is to evaluate safety, tolerability, pharmacokinetic (PK) of OJR520.

Chronic Kidney Disease

Estimated

~$10 – $8,750

Novartis PharmaceuticalsNCT07235059

Observational

Randomized Controlled Trial of Focused Shockwave, Radial Wave, and Sham Therapy for Erectile Dysfunction and Focused Shockwave and Sham Therapy for Chronic Pelvic Pain Syndrome in Patients With and Without History of Prostate Cancer

The purpose of this study to perform a randomized, sham controlled analysis of the effectiveness of both fSWT and rWT in the relief of erectile dysfunction and…

Erectile Dysfunction Due to Arterial InsufficiencyErectile DysfunctionErectile Dysfunction Due to Arterial Disease+4 more

Estimated

~$10 – $6,250

The Cleveland ClinicNCT05868668

Observational

Brain Organization, Development, and Response to Intervention in Individual Neonates

The goal of this study is to learn about brain connectivity and if massaging babies shortly after birth has an impact. Half of the recruited babies will receiv…

Development, Infant

Estimated

~$10 – $6,250

Washington University School of MedicineNCT05843396

Observational

Ketone Supplementation as a Strategy to Reduce the Negative Health Effects of High Dietary Salt in Older Adults

Most Americans consume excess dietary salt based on the recommendations set by the American Heart Association and Dietary Guidelines for Americans. High dietar…

Salt; ExcessHypertensionAging+2 more

Estimated

~$10 – $6,250

Indiana UniversityNCT06868719

Phase 1

Phase I/II of the Combination of Fludarabine, Cytarabine, Idarubicin, G-CSF (FLAG-Ida) With Venetoclax and Asciminib in Patients With Advanced Phase Chronic Myeloid Leukemia and Philadelphia Chromosome-Positive Acute Myeloid Leukemia

The goal of Phase 1b is to establish the safety of asciminib in combination with FLAG-Ida and venetoclax in patients with CML-MBP, CML-LBP, and Ph+ AML. The go…

Myeloid Leukemia

Estimated

~$10 – $6,250

M.D. Anderson Cancer CenterNCT07604233

Phase 2

PODOMOUNT-Basket, a Phase II, Multicentre, Randomised, 2-arm Parallel-group, Double-blind, Placebo-controlled Basket Trial to Assess Safety, Tolerability, PK, and Efficacy of BI 764198 in Four Proteinuric Kidney Diseases

This study is open to adults with certain kidney conditions, including secondary focal segmental glomerulosclerosis (sFSGS), treatment-resistant primary minima…

Proteinuric Kidney Diseases

Estimated

~$10 – $7,500

Boehringer IngelheimNCT07355296

Phase 3

A Phase 3 Open-label, Randomized, Active-controlled, Multicenter Trial to Evaluate the Efficacy and Safety of Orally Administered BAY 2927088 Compared With Standard of Care as a First-line Therapy in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) With HER2-activating Mutations

Researchers are looking for a better way to treat people who have advanced non-small cell lung cancer (NSCLC) with specific genetic changes called human epider…

Advanced Non-small Cell Lung Cancer, HER2 Mutation

A US Phase 3b, Multi-center, Randomized, Double-blind, Double-Dummy Study to Evaluate Efficacy of Remibrutinib Compared to Dupilumab at Early Timepoints in Adults With Chronic Spontaneous Urticaria Inadequately Controlled by Second Generation H1-Antihistamines

This is a US, multi-center, randomized, double-blind, double-dummy, Phase 3b study to evaluate efficacy of remibrutinib (25 mg twice daily \[b.i.d.\] by mouth …

Chronic Spontaneous Urticaria (CSU)

Estimated

~$10 – $8,750

Novartis PharmaceuticalsNCT06868212

Phase 2

A Phase II Study of Allogeneic Hematopoietic Stem Cell Transplant for Patients With Inborn Errors of Immunity

Background: During a transplant, blood stem cells from one person are given to someone else. The cells grow into the different cells that make up the immune s…

Lymphoproliferative DisordersAutoimmune LymphoproliferativeImmune System Diseases+2 more

Estimated

~$10 – $5,625

National Cancer Institute (NCI)NCT04339777

Phase 2

A Phase 2, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Monotherapy, Multicenter Study to Evaluate the Efficacy and Safety of BMS-986511 in Two Sequential Parts in Participants With Major Depressive Disorder

A Study to Evaluate BMS-986511 in Adults with Major Depressive Disorder

Major Depressive Disorder

Estimated

~$10 – $7,500

Bristol-Myers SquibbNCT07772531

Phase 3

A Phase 3, Randomized, Double-Blind, Placebo-controlled, Multicenter, Parallel-group Study to Evaluate the Efficacy and Safety of Once Daily Treprostinil Palmitil Inhalation Powder in Participants With Pulmonary Arterial Hypertension

The primary objective of this study is to evaluate the effect of 24-weeks of once daily treatment with TPIP compared with placebo on exercise capacity in adult…

Pulmonary Arterial Hypertension

Estimated

~$10 – $8,750

Insmed IncorporatedNCT07481981