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A Phase II Study of Binimetinib in Combination With Imatinib in Patients With Advanced KIT-Mutant Melanoma

This phase II trial studies how well binimetinib and imatinib work in treating patients with stage III-IV KIT-mutant melanoma that cannot be removed by surgery…

Melanoma Stage IIIMelanoma Stage IV

Estimated

~$10 – $5,625

University of California, San FranciscoNCT04598009

Phase 2

A Phase 2 Randomized Stepped Wedge Study of Emapalumab in APECED Enteritis

Background: Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), also known as Autoimmune polyendocrine syndrome type-1 (APS-1), is a dise…

Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy Enteritis

Estimated

~$10 – $5,625

National Institute of Allergy and Infectious Diseases (NIAID)NCT07202598

Phase 4

Evaluation of Fecal Microbiome Changes After Antegrade Continence Enema Placement and Initiation of Bowel Flush Regimen

This study will evaluate changes in the fecal microbiome in constipated pediatric patients before and after antegrade continence enema placement and initiation…

Constipation

Estimated

~$10 – $6,250

Indiana UniversityNCT05821309

Evaluation and Treatment of Neurosurgical Disorders

Objective: This protocol is designed to allow the Surgical Neurology Branch to evaluate and treat the neurosurgical disorders of protocol participants. The par…

Neurologic Disorders

Estimated

~$10 – $675

National Institute of Neurological Disorders and Stroke (NINDS)NCT00060541

Phase 4

A Randomized Controlled Trial Comparing Renal Effects of Vancomycin Combined With Either Piperacillin/Tazobactam or Meropenem: VPT Patient Safety (VPS) Study

The VPT Safety Trial (VPS) compares two common antibiotic combinations to see how they affect the kidneys of patients in the hospital with serious infections. …

InfectionAcute Kidney InjurySepsis

Estimated

~$10 – $7,500

Bassett HealthcareNCT07556107

Phase 1

A Phase Ib/II Open-label, Multi-center Study of AMO959 With Lutetium (177Lu) Vipivotide Tetraxetan (AAA617) in Combination With an Androgen Receptor Pathway Inhibitor (ARPI) in Adult Participants With PSMA-positive Metastatic Castration Resistant Prostate Cancer (mCRPC)

The purpose of this phase Ib/II study is to (a) in Phase Ib evaluate the safety, tolerability, and pharmacokinetics (PK) of AMO959 when given in combination wi…

PSMA-positive Metastatic Castration Resistant Prostate Cancer (mCRPC) With Prior Exposure to One Prior ARPI Who Are Candidates for Taxane-based Chemotherapy

Estimated

~$10 – $8,750

Novartis PharmaceuticalsNCT07226986

Phase 3

A Phase 3, Randomized, Double-Blind, 48-Week Placebo-Controlled Study to Assess the Efficacy, Safety, and Tolerability of DYNE-101 Administered to Participants With Myotonic Dystrophy Type 1

The purpose of the study is to assess the efficacy, safety, and tolerability of zeleciment basivarsen (DYNE-101) for the treatment of myotonic dystrophy 1 (DM1…

Myotonic Dystrophy Type 1 (DM1)DM1Myotonic Dystrophy+2 more

Estimated

~$10 – $8,750

Dyne TherapeuticsNCT07486934

Phase 2

A Phase IIb Randomized, Double-blind, Placebo-controlled, Parallel, Multidose Study to Evaluate the Efficacy, Safety, and PK of AZD0292 in Participants 12 Years of Age and Older With Bronchiectasis and Chronic Pseudomonas Aeruginosa Colonization

AZD0292 is a bispecific IgG1k mAb being evaluated for the prevention of exacerbations in bronchiectasis patients chronically colonized with PsA.

Bronchiectasis With Pseudomonas Aeruginosa Colonization

Estimated

~$10 – $7,500

AstraZenecaNCT07088926

Phase 3

Vitamin D and Type 2 Diabetes, Treat-To-Target

This study tests whether taking a weekly dose of vitamin D, with the dose adjusted to reach a target blood vitamin D level, can help control blood sugar levels…

PrediabetesType 2 Diabetes (T2DM)

Estimated

~$10 – $6,250

Tufts Medical CenterNCT07448974

Observational

Walking Function in Individuals With Diabetic Peripheral Neuropathy: Biomechanical Mechanisms and Implications for Clinical Outcomes and Gait Retraining

The purpose of this study is to 1) examine the differences in walking function and movement patterns between individuals with diabetic peripheral neuropathy an…

Diabetic Peripheral Neuropathy

Estimated

~$10 – $7,500

Florida Institute for Human and Machine CognitionNCT05965336

Observational

A Prospective Study Evaluating Clinical Hiatal Hernia Outcomes Using OviTex® Reinforced Tissue Matrix

This study will evaluate hiatal hernia recurrence rate and post-operative complications following the use of OviTex Core Resorbable or OviTex 1S Resorbable.

Hiatal Hernia

Estimated

~$10 – $8,750

Tela Bio IncNCT07070115

Phase 1

The Potential Therapeutic Effects of Psychedelic, N, N-dimethyltryptamine (DMT), on Alcohol Use Disorder (AUD)

This proposed study is a double-blind, randomized, placebo-controlled, parallel-group, laboratory study to determine the effects of DMT, plus psychotherapy, on…

Alcohol Use Disorder (AUD)Alcohol-Related DisordersAlcohol Use

Estimated

~$10 – $6,250

Yale UniversityNCT06070649