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IAP-086-1: A Phase 1 Single Ascending Dose First-Time in Human Study of the Safety, Tolerability and Pharmacokinetics of IAP086 in Persons With HIV-1 on Antiretroviral Therapy

Purpose: To assess the safety and tolerability of a single dose of IAP086 in persons with HIV suppressed on stable ART Participants: 30 people from UNC within …

HIV-1-infection

Estimated

~$10 – $6,250

University of North Carolina, Chapel HillNCT07596888

Respiratory Virus Sampling and Repository

Background: Respiratory viruses, like the flu or COVID-19, cause significant illness and death worldwide. Researchers want to collect samples from people with…

InfluenzaCOVID-19

Estimated

~$10 – $675

National Institute of Allergy and Infectious Diseases (NIAID)NCT05266222

Phase 3

Phase III Prospective Randomized Trial of Primary Lung Tumor Stereotactic Body Radiation Therapy Followed by Concurrent Mediastinal Chemoradiation for Locally-Advanced Non-Small Cell Lung Cancer

This phase III trial compares the effect of adding stereotactic body radiation therapy (SBRT) to the usual treatment (conventional image guided radiation thera…

Locally Advanced Lung Non-Small Cell CarcinomaStage IIB Lung Cancer AJCC v8Stage III Lung Cancer AJCC v8

Estimated

~$10 – $7,500

NRG OncologyNCT05624996

Phase 2

Treatment of Newly Diagnosed Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia in Adolescents and Young Adults (AYAs)

The goal of this research study is to evaluate a chemotherapy regiment for the treatment of newly diagnosed Philadelphia chromosome-negative acute lymphoblasti…

Acute Lymphoblastic LeukemiaPhiladelphia Chromosome-Negative Lymphoblastic LeukemiaAcute Lymphoblastic Leukemia (ALL)+1 more

Estimated

~$10 – $7,500

Dana-Farber Cancer InstituteNCT07227584

Observational

An Experiment Evaluating the Effectiveness of Counter-marketing Food Messages Among Young Adults

The primary objective of this study is to identify the food counter-marketing messages (i.e., messages that describe deceptive marketing tactics used by food c…

Diet QualityYoung Adult HealthCommunication

Estimated

~$10 – $6,250

Stanford UniversityNCT07768462

Observational

Developing a Smartphone Application to Support the Functional Needs of Veterans in Medication Treatment for Opioid Use Disorder

Opioid Use Disorder (OUD) is a complex, chronic condition affecting nearly 70,000 Veterans who can experience significantly reduced quality of life (e.g., poor…

Estimated

~$10 – $5,625

VA Office of Research and DevelopmentNCT06454903

Phase 3

Phase III Randomized Trial of IO-Based Systemic Treatment +/- Liver SBRT in Hepatocellular Cancer With Macrovascular Invasion (HELIO-RT)

This phase III trial compares the effect of immunotherapy (IO) with stereotactic body radiation therapy (SBRT) to IO alone in treating patients with liver canc…

Advanced Hepatocellular CarcinomaStage III Hepatocellular Carcinoma AJCC v8Stage IV Hepatocellular Carcinoma AJCC v8

Estimated

~$10 – $7,500

NRG OncologyNCT07166406

Phase 2

A Phase 2 Trial of Nemtabrutinib in Combination With Brexu-cel for Patients With Relapsed/Refractory Mantle Cell Lymphoma

This phase II trial tests the effect of nemtabrutinib in combination with brexucabtagene autoleucel (brexu-cel) in treating patients with mantle cell lymphoma …

Recurrent Mantle Cell LymphomaRefractory Mantle Cell Lymphoma

Estimated

~$10 – $6,250

Vanderbilt-Ingram Cancer CenterNCT07673367

Phase 3

A PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO ASSESS THE EFFICACY AND SAFETY OF ONCE-MONTHLY PF-08653944 IN ADULTS WITH OVERWEIGHT OR OBESITY (VESPER-6)

The purpose of this clinical study is to learn about the effects and safety of berobenatide (PF-08653944). This may help people with overweight or obesity lose…

ObesityOverweight and/or ObesityOverweight

Phase 1b/2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study Assessing the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of HS235 Added to Background Treatment in Adults With PAH

Phase 1b/2 Study of HS235 Assessing the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of the Activin Signaling Inhibitor HS235 Added to Background T…

Pulmonary Arterial Hypertension

Estimated

~$10 – $8,750

35Pharma IncNCT07143448

Phase 1

A Phase 1, Open-Label, Multicenter, First-In-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of APR-1051 in Patients With Advanced Solid Tumors

The purpose of this study is to assess the safety and effectiveness of APR-1051 through the performance of a Phase 1, open-label, safety, PK, and preliminary e…

Advanced Solid Tumor

Estimated

~$10 – $8,750

Aprea TherapeuticsNCT06260514

Observational

Using Novel Labeling to Improve Public Understanding of Nicotine in Electronic Nicotine Delivery Systems (ENDS): Nicotine Concentration and Nicotine Flux

Current labels for the nicotine in e-cigarette/vaping products do not sufficiently convey information to the public. The aims of this study include developing …

Nicotine Labeling for E-cigarettes

Estimated

~$10 – $6,250

Yale UniversityNCT07553585