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27,370 recruiting studies available now

Intraoperative Methadone for Postoperative Pain Management in a Head and Neck Oncology Population - A Prospective, Randomized Controlled Trial

This phase IV trial compares how well methadone plus standard fentanyl given during surgery (intraoperative) works compared to intraoperative standard fentanyl…

Head and Neck CarcinomaHypopharyngeal CarcinomaLaryngeal Carcinoma+2 more

Estimated

~$25 – $1,500

Actual pay is set by the research site.

OHSU Knight Cancer InstituteNCT07857655

Observational

Feasibility Study of a Brief Intervention to Support Medication Collaboration Among Older Adults and Family Care Partners

This study examines the feasibility and acceptability of a brief medication collaboration intervention among older adults (age 60+) with early-stage dementia o…

Dementia Family CaregiverDementiaMedication Adherence

Estimated

~$10 – $750

Actual pay is set by the research site.

Northwestern UniversityNCT07742189

Phase 1

Neural Mechanisms of Floatation-REST Therapy for Post-Traumatic Stress Symptoms in Frontline Healthcare Workers

This early-stage pilot trial aims to examine the feasibility, tolerability, and safety of Floatation-REST, or Reduced Environmental Stimulation Therapy via flo…

Posttraumatic Stress SymptomsBurnoutBurnout, Healthcare Workers+4 more

Estimated

~$150 – $4,200

Actual pay is set by the research site.

Laureate Institute for Brain Research, Inc.NCT07710417

Phase 3

Lumateperone for Late-Life Depression

The purpose of this research study is to examine how well a medication called lumateperone (Caplyta) works to relieve depression in older adults with treatment…

Treatment Resistant Depression (TRD)Late Life Depression (LLD)Depression / Major Depressive Disorder

Estimated

~$50 – $2,250

Actual pay is set by the research site.

Eric LenzeNCT07623135

Observational

A Randomized Controlled Trial of the Mobile Anger Reduction Intervention for Veterans

Difficulty controlling anger is the most commonly reported reintegration concern among combat Veterans, especially those with a diagnosis of posttraumatic stre…

Posttraumatic Stress DisorderAnger

Estimated

~$10 – $675

Actual pay is set by the research site.

VA Office of Research and DevelopmentNCT06094933

Surgical Joint Registry

The purpose of this study is to follow the patient's short term and long term clinical outcome after undergoing joint replacement surgery.

Osteoarthritis, KneeOsteoarthritis, Hip

Estimated

~$10 – $750

Actual pay is set by the research site.

Memorial Bone and Joint Research FoundationNCT03484325

Phase 4

A Phase 4, Randomized, Open Label Study to Evaluate the Safety and Tolerability of Twice Daily Xanomeline/Trospium Chloride (KarXT) With Prophylactic and PRN Antiemetic Use in Healthy Volunteers

This study looks at how to reduce nausea and vomiting in people taking KarXT which is used to treat mental health conditions like schizophrenia. KarXT can caus…

Healthy Volunteers

Estimated

~$25 – $1,400

Actual pay is set by the research site.

Karuna Therapeutics, Inc., a Bristol Myers Squibb companyNCT07681076

Phase 1

A Phase 1/1b Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of AMG 410 Alone and in Combination With Other Agents in Participants With KRAS Altered Advanced or Metastatic Solid Tumors

The purpose of this first-in-human study is to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary efficacy of AMG…

KRAS Altered Advanced or Metastatic Solid Tumors

Estimated

~$150 – $4,500

Actual pay is set by the research site.

AmgenNCT07094113

Phase 1

Pilot Trial of a DNA Vaccine Encoding Prostatic Acid Phosphatase (pTVG-HP) and PD-1 Blockade, With Targeted Ablation of Resistant Lesions, in Patients With Non-Castrate Recurrent Oligometastatic Prostate Cancer

The goal of this clinical trial is to learn whether an experimental vaccine called pTVG-HP ("vaccine" or "DNA vaccine"), combined with a drug called nivolumab …

Prostate Cancer PatientsNon-castrate Prostate CancerRecurrent Prostate Cancer+1 more

Estimated

~$150 – $3,000

Actual pay is set by the research site.

University of Wisconsin, MadisonNCT07090148

Phase 2

A Phase II Study of Induction/Window of Opportunity Toripalimab Followed by Definitive Chemoradiotherapy (CRT) and Adjuvant Toripalimab for Patients With Locally Advanced Esophageal Squamous Cell Carcinoma (ESCC)

This is a phase 2/window of opportunity study to determine the efficacy, by clinical complete response, and safety of induction toripalimab (PD-1 inhibitor) fo…

Esophageal Squamous Cell Carcinoma

Estimated

~$75 – $2,000

Actual pay is set by the research site.

Vanderbilt-Ingram Cancer CenterNCT07836049

Phase 1

A Phase I, Open-label, Dose Finding, Safety, Tolerability and Exploratory Trial of THEO-260 Administered Via an Intraperitoneal Route in Patients With High Grade Serous or Endometrioid Ovarian Cancer

A research study evaluating a new oncolytic virus, THEO-260, in patients with advanced ovarian cancer. The trial will investigate different doses of THEO-260 a…

Ovarian Cancer

Estimated

~$150 – $4,200

Actual pay is set by the research site.

Theolytics LimitedNCT07211659

Phase 2

Omission of Immediate Postoperative Radiation in Patients With Intermediate Pathological Risk Features and Negative Two-Week Post-Operative ctHPVDNA (OPERATION Trial)

This single-arm Phase II trial evaluates whether omission of postoperative radiotherapy is feasible and oncologically safe in select patients with HPV-associat…

Squamous Cell CarcinomaHuman Papilloma Virus (HPV)Oropharyngeal Squamous Cell Carcinoma (OPSCC)

Estimated

~$75 – $2,000

Actual pay is set by the research site.

Medical University of South CarolinaNCT07513389