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Testing the Use of VA Peer Specialists to Prevent Veteran Suicide

This study examines a novel way to prevent suicide among Veterans with serious mental illness (SMI). It will assess the efficacy of PREVAIL-VA, a 3-month inter…

Suicide Risk

Estimated

~$10 – $5,625

VA Office of Research and DevelopmentNCT07286383

Observational

A Pediatric Emergency Department-based Intervention to Increase Infant Adherence to Safe Sleep Practices

Safe sleep recommendations from the American Academy of Pediatrics (AAP) are designed to reduce the risk of sudden infant death syndrome (SIDS) and other sleep…

Infant Safe Sleep PracticesSIDS

Estimated

~$10 – $6,250

State University of New York at BuffaloNCT07779512

Phase 3

A Phase 3 Randomized, Open-Label Study of Atebimetinib in Combination With the Modified Gemcitabine and Nab-Paclitaxel Regimen Versus the Standard Gemcitabine and Nab-Paclitaxel Regimen for the Treatment of Patients With Metastatic Pancreatic Ductal Pancreatic Adenocarcinoma Cancer (MAPKeeper 301)

The purpose of this study is to evaluate the safety and efficacy of atebimetinib in combination with modified GnP compared with SOC GnP alone.

Pancreatic CancerPancreatic Cancer MetastaticPDAC+5 more

Estimated

~$10 – $8,750

Immuneering CorporationNCT07562152

Phase 1

Pilot Study of Anti-CD19 Chimeric Antigen Receptor T Cells (CAR-T Cells) for the Treatment of Relapsed/Refractory CD19+ Malignancies

This is an open label, non-randomized, phase 1 study of anti-CD19 CAR-T cells against relapsed CD19 positive NHL, CLL and ALL based in a lymphodepletion regime…

Acute Lymphoblastic LeukemiaDiffuse Large B Cell Lymphoma

Estimated

~$10 – $6,250

University of UtahNCT06227026

Phase 3

A Phase 3, Randomized, Open-label, Multicenter Clinical Study to Evaluate the Safety and Efficacy of MK-1084, Cetuximab, and mFOLFOX6 Versus mFOLFOX6 With or Without Bevacizumab as First-line Treatment of Participants With KRAS G12C-mutant, Locally Advanced Unresectable or Metastatic Colorectal Cancer (KANDLELIT-012)

Researchers are looking for other ways to treat locally advanced or metastatic colorectal cancer (mCRC) that is unresectable and has a gene mutation called KRA…

Colon AdenocarcinomaRectal Adenocarcinoma

Estimated

~$10 – $8,750

Merck Sharp & Dohme LLCNCT06997497

Phase 2

Randomized, Placebo-Controlled, Phase 2 Clinical Trial to Evaluate LY4065967 for the Treatment of Osteoarthritis

The main purpose of this study is to test the safety and efficacy of study drug for the treatment of knee pain due to osteoarthritis (OA). This trial is part o…

Osteoarthritis, KneeChronic Pain

Estimated

~$10 – $7,500

Eli Lilly and CompanyNCT07641517

Phase 3

A Phase 3, Open-Label, Multicenter, Randomized Study of Subcutaneous vs Intravenous Tarlatamab in Participants With Relapsed Extensive-Stage Small Cell Lung Cancer After Platinum-based First-line Chemotherapy (DeLLphi-315)

The primary objective of this study is to demonstrate non-inferiority in pharmacokinetic (PK) parameters of subcutaneous (SC) vs intravenous (IV) tarlatamab ad…

Small Cell Lung Cancer

A Phase 1a/1b Open Label, Multicenter, Dose Escalation and Dose Expansion Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Activity of DBC-664 in Adult Patients With Locally Advanced or Metastatic Solid Tumors

DBC-664-ONC-101 is a first-in-human Phase 1a/1b open-label, multicenter study to evaluate the safety, tolerability, PK, pharmacodynamic, and preliminary anti-t…

Malignant Germ Cell TumorLung AdenocarcinomaGastric/Esophageal/Gastroesophageal Junction (GEJ) Adenocarcinoma+3 more

Estimated

~$10 – $8,750

Duboce Biopharmaceuticals, Inc.NCT07705035

Validating Dietary Quality Measures and Exploring Barriers to Healthy Eating Among Older Adults in Los Angeles

The goal of this observational study is to learn about dietary quality and barriers to healthy eating among older adults who participate in the Los Angeles Cou…

None Volunteer

Estimated

~$10 – $750

University of California, Los AngelesNCT07780708

Observational

A Pilot Randomized Controlled Trial to Improve Outpatient Initiation of Medication for Opioid Use Disorder (MOUD) Following Hospitalization: The TRTME (Tailored Overdose Risk Feedback, Testimonials for MOUD Treatment, and Education on MOUD and Opioid Overdose) Trial

The primary objective of this study is to evaluate the ability of TRTME to increase initiation of MOUD outpatient treatment and MOUD knowledge in hospitalized …

Opioid Use DisorderOpioid Use Disorder, ModerateOpioid Use Disorder, Severe

Estimated

~$10 – $7,500

T. John Winhusen, PhDNCT07780097

Observational

Improving TRansitions ANd OutcomeS for Heart FailurE Patients in Home Health CaRe (I-TRANSFER-HF): A Type 1 Hybrid Effectiveness- Implementation Trial

This study is trying to improve the hospital-to-home transition for people with heart failure who receive home care services. The study will test an interventi…

Heart Failure

Estimated

~$10 – $6,250

Weill Medical College of Cornell UniversityNCT06118983

Phase 3

A Phase 3 Study to Investigate the Efficacy and Safety of Orforglipron Once Daily in Participants Who Have Obesity or Overweight and Osteoarthritis of the Knee: A Multicenter, Randomized, Double-Blind, Parallel-Arm, Placebo-Controlled Trial

The GZPT master protocol will support two independent studies, J2A-MC-GZT1 and J2A-MC-GZT2. Each study will see how well and safely orforglipron works in peopl…

Osteoarthritis

Estimated

~$10 – $7,500

Eli Lilly and CompanyNCT07153471