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A Phase 2, Open-Label, Ascending Dose Study of KER-050 for the Treatment of Anemia in Patients With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS)

The main aim of this study is to learn how safe elritercept is and how well adults with anemia associated with lower-risk MDS tolerate treatment with different…

Myelodysplastic SyndromesCytopenia

Effect of Dose Timing of Coupled Intravesical Gentamicin and Lactobacillus Rhamnosus LGG on Success and Length of Colonization in Men and Women With SCI/D and NLUTD

The main objective of the proposed research study is to determine in men and women with spinal cord injury/disease and neurogenic bladder whether the dose of c…

Spinal Cord InjuryNeurogenic Bladder (NB)Neurogenic Lower Urinary Tract Dysfunction+3 more

Estimated

~$10 – $7,500

Medstar Health Research InstituteNCT07643974

Phase 1

A Phase 1b/2, Open-Label, Master Protocol Study of BTK-Degrader BGB-16673 in Combination With Other Agents in Patients With Relapsed or Refractory B-Cell Malignancies

The purpose of this study is to measure the safety, preliminary antitumor activity, pharmacokinetics, and pharmacodynamics with tacabrutideg in combination wit…

B-cell MalignancyRelapsed CancerRefractory Cancer+1 more

Estimated

~$10 – $7,500

BeOne MedicinesNCT06634589

Natural History Study of CADASIL

Background: CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarct and leukoencephalopathy) is a genetic disorder. It causes narrowing of …

Cardiovascular DiseaseArterial StiffnessGermline Mutation in the NOTCH 3 Gene+2 more

Estimated

~$10 – $675

National Heart, Lung, and Blood Institute (NHLBI)NCT05072483

Phase 3

A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Obesity or Overweight, Without Type 2 Diabetes

The purpose of this study is to evaluate the efficacy and safety of eloralintide in adults with obesity or overweight who do not have type 2 diabetes. The stud…

ObesityOverweight

Estimated

~$10 – $7,500

Eli Lilly and CompanyNCT07321886

Phase 1

A Phase 1b, Multicenter, Randomized, Double-Blind, Dose-Escalation, Placebo-Controlled Study to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, And Early Signs of Efficacy of Orally Administered LTX-001 As Monotherapy in Adult Participants With Acute Exacerbation of Schizophrenia

The purpose of this clinical trial is to learn whether the investigational drug LTX-001 is safe and well tolerated in adults with a diagnosis of schizophrenia …

Schizophrenia

Estimated

~$10 – $8,750

Leal Therapeutics, IncNCT07734493

Phase 4

The Effect Of Lisinopril On Polycythemia

The purpose of this study is to evaluate the effect of the (angiotensin-converting enzyme) ACE inhibitor lisinopril on hemoglobin, hematocrit, and erythropoiet…

Polycythemia

Estimated

~$10 – $6,250

Mayo ClinicNCT07594535

Phase 4

Oral Methadone In Cardiac Surgery

The purpose of this study is to compare the effects of administration of oral methadone preoperatively and intravenous methadone upon induction of general anes…

Pain, PostoperativeAnesthesiaCardiac Surgery

Estimated

~$10 – $6,250

Mayo ClinicNCT07221617

Phase 3

aPCC and Emicizumab Safety Study in Congenital Hemophilia A Patients With Inhibitors (SAFE Study: Safety of aPCC Following Emicizumab Prophylaxis)

The purpose of the aPCC-emicizumab safety study is to investigate the hemostatic efficacy as measured by thrombin generation, of a low personalized dose of aPC…

Hemophilia A

Estimated

~$10 – $6,250

Emory UniversityNCT04563520

Phase 1

A Phase 1 Open-Label Safety and Immunogenicity Trial of OCU500, ChAd36 Vector Encoding SARS-CoV-2 Spike, A Next-Generation SARS-CoV-2 Booster Vaccine Via Intranasal and Inhalational Routes, in Previously Vaccinated Adults

This phase 1 randomized, open-label, dose-escalation clinical trial evaluates the safety and immunogenicity of OCU500, a ChAd36 Vector Encoding SARS-CoV-2 Spik…

COVID-19

Estimated

~$10 – $5,625

National Institute of Allergy and Infectious Diseases (NIAID)NCT07536308

Phase 2

A Phase 2, Double-blind, Placebo-Controlled Study to Evaluate LY3537021 for the Treatment of Chemotherapy-Induced Nausea and Vomiting in Adult Participants With Malignant Disease

The purpose of this study is to check how well LY35327021 works and how safe it is for controlling nausea and vomiting caused by chemotherapy. Participants who…

NauseaVomitingDrug-Related Side Effects and Adverse Reactions+1 more

Estimated

~$10 – $7,500

Eli Lilly and CompanyNCT07169851

Phase 2

A Phase II, Multi-site, Open-label, Dose-titration Trial to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of Lu AG13909 in Adults With Cushing's Disease

This trial will evaluate the effects of Lu AG13909 in adult participants with Cushing's disease (CD). CD is a rare and serious disorder where the body makes to…

Cushing's Disease

Estimated

~$10 – $7,500

H. Lundbeck A/SNCT06471829