Washington University School of Medicine
In this study the investigators will incorporate a wide range of clinical variables associated with aging and cardiovascular disease to determine whether they are associated with mutation status independent of chronologic age. Clinically, aging can be operationalized using geriatric assessment, which entails a comprehensive multi-dimensional assessment of the health of an older adult, including measures of comorbidity, polypharmacy, functional status, cognition, depression, falls, social activities and social support. Given that aging is heterogeneous, geriatric assessment allows greater specificity for aging than chronological age alone.
Inclusion Criteria: * At least 50 years of age. * Able to understand written and spoken English. * Able to understand and willing to sign an IRB-approved written informed consent document (or that of a legally authorized representative, if applicable for the trauma cohort) Exclusion Criteria: * Inability or unwillingness to complete health questionnaire (with the exception of hip and knee replacement participants). * History of a recent (\<30 days) acute viral illness. * Current cancer diagnosis and currently receiving chemotherapy or undergoing radiation therapy. A prior history of cancer…
-Baseline and no more frequently than every 6 months until death
* 10 items about daily functional status * Baseline and no more frequently than every 6 months until death
* 7 items about daily functional status * Baseline and no more frequently than every 6 months until death
* 1 item about daily functional status * Baseline and no more frequently than every 6 months until death
* 1 item about daily functional status * Baseline and no more frequently than every 6 months until death
* 13 items about comorbidity * Baseline and no more frequently than every 6 months until death
* 4 items about social activity * Baseline and no more frequently than every 6 months until death
* 2 items about nutrition * Baseline and no more frequently than every 6 months until death
-Baseline and no more frequently than every 6 months until death
* Participants will rinse their mouths 2 times with water for 20-30 seconds and discard the expectorated sample. One side of the inner cheek (buccal mucosa) will then be scraped with a cotton swab 20 times (alternatively, the tongue will be brushed 20 times with a toothbrush) * Baseline and no more frequently than every 6 months until death
* 7 items about heart health and smoking history * Baseline and no more frequently than every 6 months until death
* Research coordinator will test gait speed * Baseline and no more frequently than every 6 months until death
* Research coordinator will test grip strength * Baseline and no more frequently than every 6 months until death
-Baseline and no more frequently than every 6 months until death
-Baseline and no more frequently than every 6 months until death
-1 optional bone marrow biopsy
-For Arm E only
Hip replacement participants only
Knee replacement participants only
Hip and knee replacement participants only
Arctuva estimate
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