Aging, Geriatric Syndromes and Clonal Hematopoiesis

Summary

In this study the investigators will incorporate a wide range of clinical variables associated with aging and cardiovascular disease to determine whether they are associated with mutation status independent of chronologic age. Clinically, aging can be operationalized using geriatric assessment, which entails a comprehensive multi-dimensional assessment of the health of an older adult, including measures of comorbidity, polypharmacy, functional status, cognition, depression, falls, social activities and social support. Given that aging is heterogeneous, geriatric assessment allows greater specificity for aging than chronological age alone.

Eligibility

Age range

50+ years

Sex

All

Healthy volunteers

Yes

Interventions

• Other
  Cognitive Assessment

  -Baseline and no more frequently than every 6 months until death

• Other
  Activities of Daily Living Questionnaire

  * 10 items about daily functional status * Baseline and no more frequently than every 6 months until death

• Other
  Instrumental Activities of Daily Living, subscale of the OARS

  * 7 items about daily functional status * Baseline and no more frequently than every 6 months until death

• Other
  Karnofsky Self-reported Performance Rating Scale

  * 1 item about daily functional status * Baseline and no more frequently than every 6 months until death

• Other
  Number of Falls

  * 1 item about daily functional status * Baseline and no more frequently than every 6 months until death

• Other
  Physical Health Section, subscale of the OARS

Location