The Oxford Risk Factors And Non-Invasive Imaging Study
University of Oxford
Summary
ORFAN is a prospective, multi-centre, multi-ethnic cohort observational study collecting CT scans, biological material and outcomes data, to develop and validate novel biomarkers of cardiometabolic and other disease risk.
Description
The ORFAN registry will include unselected, consecutive patients undergoing CT scans (coronary CT angiograms (CCTA), CT chest, abdomen and pelvis scans) collected at the participating centres. The study will combine imaging data with patient demographics and clinical information (including prospective outcomes) to aid the development and/or validation of new or existing image analysis algorithms and software tools to improve diagnosis, clinical risk discrimination and prediction. Specifically, ORFAN will evaluate the specificity, utility and predictive value of newly developed image analysis m…
Eligibility
- Age range
- 18–99 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: Inclusion Criteria for study Arms 1, 2 and 3: * Participant is willing and able to give informed consent for participation in the study. * Male or Female, aged 18 -99 years. Inclusion Criteria for study Arm 4: • Male or Female, aged 18 -99 years. Exclusion Criteria: Exclusion Criteria for Study Arms 1, 2 and 3: * Unable or unwilling to consent * Active cancer Exclusion Criteria for Study Arm 4: * Participation in Study Arms 1, 2 or 3 * Existing opt-out from use of data for research purposes
Locations (37)
- NIH National Heart, Lunch, and Blood InstituteBethesda, Maryland
- Mayo ClinicRochester, Minnesota
- Cleveland Clinic Heart and Vascular InstituteCleveland, Ohio
- Flinders UniversityAdelaide
- The University of SydneySydney
- University Hospitals LeuvenLeuven