Preclinical Trials to Determine the Range of Chardonnay Mark Intake for Improved Metabolic and Vascular Response.

Summary

This study aims to obtain data on the potential influence of Vine to Bar product(s) containing Chardonnay marc on cardiometabolic health. These initial studies will inform the design and timing of data collection for future dietary intervention trials that will examine the influence of Chardonnay marc intake on outcomes/biomarkers of both cardiometabolic health and the gut microbiome. This includes collecting data on the potential differences in response to the products based on the unique food matrix for each of the products that will be tested. Moreover, as there is a paucity of data on the influence of cocoa flavanol intake on vascular function beyond 4 hours post intake, the response of the selected outcomes will be assessed after 6 hours of flavanol intake. This is a time point that captures the increased circulating presence of microbial derived flavanol metabolites.

Description

Eligibility

Age range

30–50 years

Sex

Male

Healthy volunteers

Yes

Interventions

• Other
  Low Flavanol Cocoa Powder

  Measure the response 2 and 6 hours post low flavanol cocoa intake

• Other
  High Flavanol Cocoa Powder

  Measure the response 2 and 6 hours post high flavanol cocoa intake

• Other
  Vine to Bar Chocolate - 2 servings

  Measure the response 2 and 6 hours post chocolate intake

• Other
  Vine to Bar Chocolate - 1 serving

  Measure the response 2 and 6 hours post chocolate intake

• Other
  Vine to Bar Chocolate covered almonds

  Measure the response 2 and 6 hours post chocolate covered almond intake

Location