A Master Protocol for a Randomized, Controlled, Clinical Trial of Multiple Interventions for Chronic Weight Management in Adult Participants With Obesity or Overweight

Summary

The purpose of this Phase-2 chronic weight management master protocol (CWMM) is to create a framework to evaluate the safety and efficacy of various investigational interventions for chronic weight management with intervention-specific appendices (ISAs). The CWMM establishes entry criteria for newly enrolled participants across the master and the ISAs. The ISAs may start independently of other ISAs as interventions become available for clinical testing. The results for the CWMM screening record will be reported when all the ISA's complete.

Eligibility

Age range

18–75 years

Sex

All

Healthy volunteers

No

Interventions

• Drug
  LY3305677

  Administered SC. ISA specific interventions will be listed in the ISA.

• Drug
  LY3841136

  Administered SC. ISA specific interventions will be listed in the ISA.

• Drug
  Tirzepatide

  Administered SC. ISA specific interventions will be listed in the ISA.

• Drug
  Placebo

  Administered SC. ISA specific interventions will be listed in the ISA.

• Drug
  LY3549492

  Administered orally. ISA specific interventions will be listed in the ISA.

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