The Effects of Healthy Diets With Plant Oils on Heart and Metabolic Health: A Randomized, Crossover, Controlled-feeding Study
Penn State University
Summary
This study will examine the effect of a healthy diet containing cottonseed oil compared to healthy diets containing other commonly consumed plant oils on biomarkers of heart and metabolic health after 4 weeks.
Description
This is a 3-period randomized crossover complete feeding study examining if a dietary pattern containing cottonseed oil improves lipids/lipoproteins and other cardiometabolic disease risk factors to a greater extent than a fatty acid matched diet devoid of cottonseed oil and a diet lower in polyunsaturated fatty acids (PUFA) and saturated fatty acids (SFA), but with a matched PUFA:SFA ratio
Eligibility
- Age range
- 25–60 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * LDL-C ≥100 mg/dL and ≤190 mg/dL * BMI of 25-40 kg/m2 * Blood pressure \<140/90 mmHg * Fasting blood glucose \<126 mg/dL * Fasting triglycerides \<350 mg/dL * ≤10% change in body weight for 6 months prior to enrollment Exclusion Criteria: * Type 1 or type 2 diabetes or fasting blood glucose ≥126 mg/dL * Prescription of anti-hypertensive, lipid lowering or glucose lowering drugs * Intake of supplements that affect the outcomes of interest and unwilling to cease during the study period * Diagnosed liver, kidney, or autoimmune disease * Prior cardiovascular event (e.g., st…
Interventions
- OtherHealthy Dietary Pattern with Cottonseed Oil
Cottonseed Oil
- OtherHealthy Dietary Pattern with Fatty Acid-Matched Plant Oils
Plant oil blend fatty acid matched
- OtherHealthy Dietary Pattern with PUFA:SFA Ratio-Matched Plant Oil
Plant oil with matched PUFA to SFA ratio
Location
- The Pennylvania State UniversityUniversity Park, Pennsylvania