Medical College of Wisconsin
The goal of this study is to learn how a supplement Quercetin can affect microvascular function. Participants will: * give two blood draws of 5 mL each * have a camera placed under the tongue to take pictures of blood vessels * have 2 laser Doppler microdialysis catheters placed on the forearm to monitor blood vessels before and after local drug infusion Researchers will compare blood vessel function of those who take estrogen supplements to those who do not.
Inclusion Criteria: * Obesity (BMI\>30) * Aged 18-40 years * English Speaking Exclusion Criteria: * BMI\>60 * Resting SBP ≥180 mmHg or DBP ≥ 110mmHg * Pregnancy or breastfeeding. * Prior history of myocardial infarction * Diagnosis of more than 1 risk factor for coronary artery disease (active smoker, diabetes mellitus- type 1 or 2, congestive heart failure, hyperlipidemia, hypertension) * Active mouth sores that affect the buccal mucosa.
Quercetin will be provided to take one Quercetin per day for 30 days to look for differences in microvascular function.
Subjects randomized to receive placebo will be administered a standard placebo sugar pill.
Arctuva estimate
Verify or correct the compensation shown for this listing.