Wild Blueberries for Gut, Brain, and Cardiometabolic Health in Female Adults With Prediabetes.
Georgia State University
Summary
The goal of this clinical trial is to determine the effectiveness of using a freeze-dried wild blueberry powder on cardiometabolic health, cognitive function, and gut microbiota composition in adult women with prediabetes.
Description
In the U.S., 35.3 million adults have type 2 diabetes mellitus (T2DM) and 96 million have prediabetes. Eight out of 10 people with T2DM die from cardiovascular disease. People with T2DM also have a 50% higher risk of developing dementia compared to healthy counterparts. Further, studies show that gut microbes play a major role in the development of T2DM. Prevention and treatment of T2DM focus on lifestyle changes including dietary modifications such as increased consumption of deep-colored fruits like berries. Blueberries are rich in fiber and phytochemicals and have several health benefits. W…
Eligibility
- Age range
- 20–65 years
- Sex
- Female
- Healthy volunteers
- No
Inclusion Criteria: * Women aged 20-65 years old * Prediabetes (fasting blood glucose 100-125 mg/dL and/or HbA1c percentage between 5.7-6.4) * Body Mass Index between 25-30 kg/m\^2 Exclusion Criteria: * Allergies to berries * Use of insulin, antidiabetic, antibiotics, and anti-inflammatory drugs * Active cancer, gastrointestinal, renal, thyroid, stage 1 \& 2 hypertension and other cardiovascular diseases, neurological diseases, or severe head injury * Smoking * Consumes greater than 2 alcoholic beverages per day * Consumes antioxidant, probiotic, and prebiotic supplements * Pregnant or Lact…
Interventions
- Dietary SupplementWild Blueberry
Daily consumption of 22 g of freeze-dried wild blueberry freeze-dried powder for 6 weeks
- Dietary SupplementPlacebo
Daily consumption of 22 g of freeze-dried macronutrient-matched placebo powder for 6 weeks
Location
- Georgia State UniversityAtlanta, Georgia