Brigham and Women's Hospital
The investigators are studying the impact that opioids have on breathing during sleep in healthy participants and those diagnosed with obstructive sleep apnea.
Inclusion Criteria: * Healthy controls: Apnea Hypopnea Index (AHI) \< 5 events/hr on in-laboratory PSG within 3 months of enrollment * OSA group: AHI \> 10 events/hr on in-laboratory PSG within 3 months of enrollment; treated or untreated. Exclusion Criteria: * Sleep disordered breathing or respiratory disorders (other than OSA in the OSA group), such as central sleep apnea (\>50% of respiratory events scored as central), chronic hypoventilation/hypoxemia (awake SaO2 \< 92% by oximetry) due to chronic obstructive pulmonary disease or other respiratory conditions. * Other sleep disorders: pe…
Morphine 50mg PO will be given on sleep study night.
Placebo will be given on the sleep study night.
Arctuva estimate
Verify or correct the compensation shown for this listing.