Mechanisms of Opioid-induced Respiratory Depression (OIRD) During Sleep
Brigham and Women's Hospital
Summary
The investigators are studying the impact that opioids have on breathing during sleep in healthy participants and those diagnosed with obstructive sleep apnea.
Eligibility
- Age range
- 18–65 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Healthy controls: Apnea Hypopnea Index (AHI) \< 5 events/hr on in-laboratory PSG within 3 months of enrollment * OSA group: AHI \> 10 events/hr on in-laboratory PSG within 3 months of enrollment; treated or untreated. Exclusion Criteria: * Sleep disordered breathing or respiratory disorders (other than OSA in the OSA group), such as central sleep apnea (\>50% of respiratory events scored as central), chronic hypoventilation/hypoxemia (awake SaO2 \< 92% by oximetry) due to chronic obstructive pulmonary disease or other respiratory conditions. * Other sleep disorders: pe…
Interventions
- DrugMorphine p.o.
Morphine 50mg PO will be given on sleep study night.
- DrugPlacebo
Placebo will be given on the sleep study night.
Location
- Brigham and Women's HospitalBoston, Massachusetts