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University of PittsburghNCT06806163

People Who Use Opioids/People With Opioid Use Disorder (OUD)

Prescribe to Prevent HIV (P2PH): Enhancing Clinic-based Prescribing of Harm Reduction: A Clinical Trial to Prevent HIV and Severe Injection-related Infections Among PWID

In the U.S., an estimated 3.6 million people who inject drugs (PWID) face a growing yet preventable health crisis, with rising cases of serious injection-relat…

University of PittsburghNCT07073924

SurgeryAnalgesics, Opioids

Methods for Effective Disposal of Surplus Analgesics to Facilitate Elimination

The primary objective is to evaluate the difference in outcomes for mail-in vs. in-home disposal methods for leftover prescription opioids after discharge from…

University of MichiganNCT05991687

Phase 4

Adding Dexmedetomidine or Clonidine to Spinal Anesthesia for Cesarean Delivery

This study will examine whether addition of dexmedetomidine or clonidine (two alpha-2 adrenergic agonists) will improve the comfort of patients during spinal a…

Cesarean DeliveryCesarean Delivery; Neuraxial OpioidsSpinal Anesthesia for Cesarean Section+3 more

Columbia UniversityNCT07567495

Phase 1

Mechanisms of Opioid-induced Respiratory Depression (OIRD) During Sleep

The investigators are studying the impact that opioids have on breathing during sleep in healthy participants and those diagnosed with obstructive sleep apnea.

OpioidsObstructive Sleep Apnea (OSA)

Brigham and Women's HospitalNCT06854211

People Who Use Opioids/People With Opioid Use Disorder (OUD)

Interpersonal Brain Function in Opioid Use

The purpose of this study is to assess dyadic physiological coherence and subjective empathic attunement during meditation practices and their association with…

University of California, San DiegoNCT07386769

Opioid Overdose PreventionPeople Who Use Opioids/People With Opioid Use Disorder (OUD)Reduction of Substance Use-related Stigma+2 more

Reducing Overdose and Substance Use-related Stigma on Chicago's West Side by Training Non-substance-using Friends and Family Members of People Who Use Opioids to Be Harm Reduction Champions

Fatal opioid overdoses are more frequent among populations with low access to harm reduction (HR) services and with high substance use-related stigma (which is…

University of Illinois at ChicagoNCT06823453

Young AdultsPast-3-month Non-medical Use of Prescription OpioidsWithout Substance Use Disorders+1 more

Theory-based Social Media Intervention for Non-medical Use of Prescription Opioids in Young Adults

Brief Summary The purposes of this study are to develop and implement a peer-led intervention program on Instagram for promoting prescription opioid use manag…

University of South CarolinaNCT06469749

Phase 4

Low-dose Buccal Buprenorphine: Relative Abuse Potential and Analgesia

The goal of this study is to compare the abuse potential of low-dose equianalgesic buccal buprenorphine to a commonly used full mu opioid receptor (MOR) agonis…

AnalgesiaAbuse OpioidsPain