The Use of High Bile-Binding Foods to Reduce Upper Gastrointestinal Bile Acid Concentrations: A Novel Intervention for Children at Risk for Aspiration-Associated Complications (Aim 1)

Summary

We will perform an acute physiology study comparing three different diets-an amino acid-based formula, a low bile acid-binding blenderized diet, or a high bile acid-binding blenderized diet administered through gastrostomy tube. We will determine the differences in gastric and salivary bile acid concentrations between participants over the 4 hour post-prandial timeframe. Participants who regularly receive an amino acid-based formula will receive an amino acid-based formula during the study and participants who regularly receive a blenderized feed will receive a blenderized feed during the study. Only participants who regularly receive blenderized feeds will be randomized to receive either the high or low bile acid binding blenderized feed.

Eligibility

Age range

5–21 years

Sex

All

Healthy volunteers

No

Interventions

• Drug
  amino acid based formula (e.g. Elecare Jr)

  We will administer one bolus of an amino acid based formula

• Drug
  low bile acid binding blenderized diet (e.g. Kate Farms)

  We will administer one bolus of a low bile acid binding blenderized diet

• Drug
  high bile acid binding blenderized diet

  We will administer one bolus of a high bile acid binding blenderized diet

Location