Novel Biomarkers of Non-IgE Immediate Hypersensitivity Drug Reactions
Johns Hopkins University
Summary
The goal of this clinical trial is to investigate biomarkers of non-IgE-mediated immediate hypersensitivity reactions during infusion of intravenous vancomycin. The main question it aims to answer is: • Identifying novel biomarkers in blood that occur during infusion reaction Participants will: * Have allergy skin testing for vancomycin * Receive an infusion of vancomycin
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Male or female age ≥ 18 years. * Adequate kidney function as defined by creatinine level within normal institutional limits at the participant's first visit. * Women of child bearing potential must agree to a reliable form of highly effective contraception (hormonal, device, or barrier method of birth control; abstinence) prior to study entry, for the duration of study participation, and for 7 days following completion of vancomycin therapy. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform the Principal Invest…
Interventions
- DrugVancomycin (IV)
single infusion of vancomycin in healthy volunteers
Location
- Johns Hopkins University School of MedicineBaltimore, Maryland