An Open-label, Single-sequence, Crossover Study Investigating the Influence of UBT251 on Pharmacokinetics of Index Substrates for Cytochrome P450 Enzymes in Participants With Overweight or Obesity
Novo Nordisk A/S
Summary
The purpose of this clinical study is to find out if UBT251 is safe and effective to be taken together with medicines, like midazolam, caffeine and warfarin in participants living with overweight or obesity.
Eligibility
- Age range
- 18–65 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Male or female (sex assigned at birth, inclusive of all gender identities). * Age 18-65 years (both inclusive) at the time of signing the informed consent. * BMI between 27.0-39.9 kg/m\^2 (both inclusive) at screening. Overweight should be due to excess adipose tissue, as judged by the investigator. * Body weight \>=60.0 kg. * Considered to be generally healthy, except for overweight or obesity, based on the medical history, physical examination, and the results of vital signs, electrocardiogram and clinical laboratory tests performed during the screening visit, as judge…
Interventions
- DrugUBT251
Administered subcutaneously.
- DrugCocktail (Warfarin/Caffeine/Midazolam)
Administered orally.
Location
- Altasciences Clinical LA, Inc.Cypress, California