VA Office of Research and Development
Cardiovascular disease is the leading cause of death among Veterans. Clinical trials are essential for developing better treatments, but Veterans remain underrepresented in these studies due to barriers including limited health literacy, lack of awareness, and mistrust. Current outreach approaches rely on either in-person physician conversations, which are limited by workforce constraints, or mailed letter invitations, which often fail to engage Veterans with limited health literacy. This study tests whether AI-generated video avatars can improve Veteran engagement in cardiovascular clinical trials.
Recent advances in artificial intelligence now enable the creation of personalized video avatars at negligible cost and time. These computer-generated videos can be rapidly adapted to describe any clinical trial and tailored to individual patient preferences in both speaker appearance and content. The EVERYVET Study (Empowering VEterans in Research effectivelY using Virtual Engagement Tools) will evaluate whether these AI-supported tools can increase Veteran engagement in cardiovascular clinical trials compared to standard mailed letter invitations. The avatar invitations will be randomly emb…
Inclusion Criteria: Inclusion Criteria: \- Veteran receiving a mailed invitation to participate in the parent VA Cooperative Studies cardiovascular trial (therefore meeting inclusion criteria of the parent VA Cooperative Studies trial) Inclusion Criteria (Aim 1 Qualitative Interviews): * Veteran receiving care at VAPAHCS * Recently invited (within 3 months) to participate in an existing cardiovascular clinical trial at VAPAHCS * Able to provide informed consent in English Inclusion Criteria (Aim 1 Beta-Testing and Aim 3): * Veteran receiving care at VAPAHCS or a participating VA-CTC site…
Veterans randomized to the intervention arm will receive the website link where they can select their preferred avatar speaker(s) from a diverse set of options and self-select content topics of interest. They may watch the self-directed tailored video to guide their decision to participate in the parent trial.
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