Metabolic Changes in PMOS Patients With Obstructive Sleep Apnea (OSA) Pilot Study
University of Chicago
Summary
The goal of this study is to obtain pilot data investigating the effects of sleep apnea on mitochondrial function and cellular metabolism in Polyendocrine Metabolic Ovarian Syndrome (PMOS) patients.
Description
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age, with symptoms commonly manifesting in reproductive abnormalities. PCOS was recently reclassified as Polyendocrine Metabolic Ovarian Syndrome (PMOS) to better describe the multi-systemic and endocrine nature of the disorder. Beyond reproductive concerns, PMOS patients are at significantly higher risk of developing diabetes. Similarly, PMOS patients are at a higher risk of presenting with Obstructive Sleep Apnea (OSA). While it is known that OSA contributes to metabolic dysfunction, this effect h…
Eligibility
- Age range
- 18–40 years
- Sex
- Female
- Healthy volunteers
- No
Inclusion Criteria: * Women 18-40 years old * PMOS diagnosis * Sleep Apnea (AHI\>5) diagnosed by home sleep test (WatchPAT One) * BMI\< 50.0 Exclusion Criteria: * Regular adherent CPAP use per clinical guidelines * Any history of bleeding disorders * Current use of anti-coagulant medication * Hemoglobin \<11.6 g/dL * Currently pregnant, pregnant within the last year, or gave birth within the last year * Any underlying disease likely to limit life span and/or increase risk of interventions including cardiovascular disease (e.g. unstable angina, heart failure requiring hospitalization in the…
Interventions
- DeviceContinuous Positive Airway Pressure (CPAP)
Two nights of CPAP treatment for OSA.
Location
- University of ChicagoChicago, Illinois