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26,914 recruiting studies available now

An Open-Label, Phase 2b, Global Multicenter Cohort Trial to Assess the Safety and Efficacy of Zipalertinib in Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer With Exon 20 Insertion and Uncommon/Single or Compound Epidermal Growth Factor Receptor Mutations.

The purpose of this study is to evaluate the safety, efficacy and pharmacokinetics (PK) of zipalertinib in participants with locally advanced or metastatic Non…

Advanced or Metastatic NSCLC Harboring Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion (ex20ins) Mutations

Estimated

~$10 – $8,750

Taiho Oncology, Inc.NCT05967689

Phase 2

Phase 2 Study of Futibatinib 20 mg and 16 mg in Patients With Advanced Cholangiocarcinoma With FGFR2 Fusions or Rearrangements

This is an open-label, multinational, randomized Phase 2 study confirming the clinical benefit of 20 mg futibatinib and evaluating the safety and efficacy of 1…

Advanced CholangiocarcinomaFGFR2 FusionsGene Rearrangement

Estimated

~$10 – $8,750

Taiho Oncology, Inc.NCT05727176

PROSPECT: A Registry and Longitudinal Natural History Study of Individuals at Risk for Genetic Prion Disease

PROSPECT is a prospective observational registry and longitudinal natural history study of adults at risk for genetic prion disease.

Prion Diseases

Estimated

~$10 – $1,125

Brian ApplebyNCT07732608

Phase 3

Prospective RandomizEd Evaluation and Management of Premature aTherosclerosis

Heart disease is the leading cause of death for men, women, and people of most racial and ethnic groups in the United States. This clinical trial will test if …

Coronary Artery Disease Risk Factors MultipleCoronary Artery Disease ProgressionPrevention & Control+1 more

Estimated

~$10 – $6,250

Duke UniversityNCT07232069

Observational

Weight Management and Black American Women: Targeting Social Networks as a Strategy to Improve Outcomes (BRIDGE & Friends)

Aim 1. Conduct a 6-month (24-session) RCT comparing MedDiet-WL to MedDiet-SN among 268 older adults with obesity (50-79 years, BMI = 30-50 kg/m²). We hypothesi…

Obesity & Overweight

Estimated

~$10 – $6,250

University of Illinois at ChicagoNCT07798557

VRC 200: A Multicenter Specimen Collection Protocol to Obtain Human Biological Samples for Research Studies

This study collects specimens from volunteers for use in studies by NIAID's Vaccine Research Center. A number of different types of specimens or samples can be…

Sample Collection

Estimated

~$10 – $675

National Institute of Allergy and Infectious Diseases (NIAID)NCT00067054

Phase 3

A Phase 3, Randomized, Active- and Placebo-Controlled, Partially-Blinded Study to Compare the Efficacy and Safety of KAI-9531 Administered Once Weekly Versus Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have Diabetes

The primary objective of this study is to demonstrate that ribupatide (KAI-9531) subcutaneous (SC) injection once weekly is superior to semaglutide SC once wee…

A First-in-Human Phase 1b, Single-Blind, Placebo-controlled Single Ascending Dose (SAD) and Multiple Ascending Dose (MAD) Study to Evaluate Safety and Pharmacokinetics of GS-0415 in People With HIV-1 Who Are Virologically Suppressed on Antiretroviral Treatment

The goals of this clinical study are to learn more about the study drug GS-0415, safety, tolerability, and pharmacokinetics (PK) of single ascending doses (SAD…

HIV -1 Infection

Estimated

~$10 – $7,500

Gilead SciencesNCT07719491

Obtaining Samples From Human Subjects to Facilitate Basic, Translational and Clinical Research

Background: This study is designed to provide samples to help us study the genes your blood cells are making as well as the proteins, sugars, fats, vitamins a…

Endothelial DysfunctionInflammation in Cardiopulmonary and Vascular Disease StatesHealthy Volunteers

Estimated

~$10 – $675

National Institutes of Health Clinical Center (CC)NCT03253705

Observational

Remedy to Diabetes Distress (R2D2): A Scalable Screen to Treat Program for School-age Families

This R01 is in response to RFA-DK-19-021, Treating Diabetes Distress to Improve Glycemic Outcomes in Type 1 Diabetes. The objective is to test the feasibility …

Type 1 Diabetes

Estimated

~$10 – $6,250

Nemours Children's ClinicNCT05268250

Visual and Patient Reported Outcomes Comparing Clareon TruPlus IOL and Tecnis Eyhance IOLs in Normal Cataract Patients: Stage 1

This study is a prospective, randomized, two-arm, single-center, single-surgeon, double-masked (subject and assessor) comparative study. It involves bilateral …

Cataract

Estimated

~$10 – $1,125

Gainesville Eye AssociatesNCT07658040

Observational

Chicago Alternative Prevention Study for BreAst CAncer inHigh Risk Women - CAPSBRACA

This study is aimed to establish a registry of women undergoing intensive surveillance for the early detection of breast cancer in high-risk women.

Breast Cancer

Estimated

~$10 – $6,250

University of ChicagoNCT03729115