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Psychological Treatments for Youth With Severe Irritability

Background: When children have severe irritability and temper outbursts, they can be so cranky or angry that it leads to problems at home, in school, and with…

Irritability

Estimated

~$10 – $675

National Institute of Mental Health (NIMH)NCT02531893

Screening and Baseline Assessment of Patients With Abnormalities of Immune Function

This study will evaluate patients with abnormal immune function that results in recurrent or unusual infections or chronic inflammation. This may include inher…

Chronic Granulomatous Disease (CGD)X-Linked Severe Combined Immune Deficiency (XSCID)Leukocyte Adhesion Deficiency 1 (LAD)+1 more

Estimated

~$10 – $675

National Institute of Allergy and Infectious Diseases (NIAID)NCT00128973

Phase 1

A Phase I, Multicentre, Single-Dose, Non-Randomised, Open-Label, Parallel-Group Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of AZD9550 and AZD6234

The purpose of this study is to examine the safety and tolerability of AZD6234 and AZD9550 in participants with hepatic impairment and participants with normal…

Hepatic Impairment

Estimated

~$10 – $7,500

AstraZenecaNCT07546760

Phase 1

An Open-label, Phase 1, Multicentre Platform Study to Evaluate the Safety and Preliminary Anti-tumour Activity of NT-175 in Human Leukocyte Antigen-A*02:01-Positive Adult Participants With Advanced Malignancies That Are Positive for the TP53 R175H Mutation

Phase I Study of NT-175, an autologous T cell therapy product genetically engineered to express an HLA-A\*02:01-restricted T cell receptor (TCR), targeting TP5…

Non-small Cell Lung CancerHead and Neck Squamous Cell CarcinomaColorectal Carcinoma+5 more

Estimated

~$10 – $7,500

AstraZenecaNCT05877599

Phase 2

A Phase II Study Evaluating Efficacy of B7-H3-CAR T Cells Administered at the End of Upfront Map Chemotherapy in Patients With Newly Diagnosed High-Risk Osteosarcoma

The purpose of this study is to assess the safety, feasibility, and effectiveness of a consolidative B7-H3 CAR T cell therapy in patients with newly diagnosed …

Pediatric Osteosarcoma

Estimated

~$10 – $6,250

St. Jude Children's Research HospitalNCT07428993

Observational

Savannah Environmental Nutrition Study (SENS) Food as Prevention: A Community-Based Nutrition Intervention to Reduce Air Pollution-Related Inflammation and Oxidative Stress in Residents Near the Port of Savannah

This pilot clinical trial will evaluate the feasibility and potential health effects of a nutrition-based intervention among adults living in communities affec…

Air Pollution ExposureOxidative StressAirway Inflammation

Estimated

~$10 – $6,250

Georgia Southern UniversityNCT07797413

Phase 3

A Phase III, Multicenter, Randomized, Open-Label Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Versus Alpelisib Plus Fulvestrant in Patients With Hormone Receptor-Positive, HER2-Negative, PIK3CA Mutated, Locally Advanced or Metastatic Breast Cancer Who Progressed During or After CDK4/6 Inhibitor and Endocrine Combination Therapy

This is a Phase III, multicenter, randomized, open-label, global study designed to evaluate the efficacy and safety of inavolisib plus fulvestrant compared wit…

Breast Cancer

Estimated

~$10 – $7,500

Hoffmann-La RocheNCT05646862

Observational

Full Exchange Pharmacokinetic Model Analysis of Dynamic Contrast-Enhanced MRI Data for Identification of Vascular Habitats and Evaluation of Treatment Response in Human Papillomavirus Positive Oropharyngeal Squamous Cell Carcinomas

The purpose of this research study is to investigate the relationship between vascular habitats and treatment response AND to investigate the potential utility…

Oropharyngeal Squamous Cell Carcinoma (OPSCC)HPVHPV Positive Oropharyngeal Squamous Cell Carcinoma

Estimated

~$10 – $6,250

Abramson Cancer Center at Penn MedicineNCT07797738

A Prospective Natural History Study of Patients With Neurofibromatosis Type 2 (NF2).

Objective With this prospective natural experiment trial on neurofibromatosis type 2 (NF2) study, we hope to understand the factors leading to tumor progressi…

Neurofibromatosis

Estimated

~$10 – $675

National Institute of Neurological Disorders and Stroke (NINDS)NCT00598351

Exploring the Use of Tumor Informed Circulating Tumor DNA (ctDNA) in High Grade Upper Tract Urothelial Cancer (UTUC)

The study will evaluate the feasibility of collecting ctDNA data for UTUC patients in perioperative setting and if the data generated can help with design of f…

Upper Tract Urothelial Carcinoma

Estimated

~$10 – $750

Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsNCT07793240

Cardiovascular Health and Needs Assessment in Washington D.C. - Development of a Community-Based Behavioral Weight Loss Intervention

Background: \- Past studies suggest that the best way to improve heart health in the Black community is through community-based programs. Researchers will par…

Cardiovascular DiseaseObesity

Estimated

~$10 – $675

National Heart, Lung, and Blood Institute (NHLBI)NCT01927783

Phase 3

A Phase 3, Randomized, Double-blind, Active-control Study of Pelabresib (DAK539) and Ruxolitinib vs. Placebo and Ruxolitinib in Adult Patients With Myelofibrosis Who Are JAK Inhibitor Naive

The purpose of this trial is to evaluate whether treatment with pelabresib in combination with ruxolitinib leads to improved clinical outcomes compared to ruxo…

Primary Myelofibrosis (PMF)Post-polycythemia Vera Myelofibrosis (PPV-MF)Post-essential Thrombocythemia Myelofibrosis (PET-MF)

Estimated

~$10 – $8,750

Novartis PharmaceuticalsNCT07357727