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A Randomized, Double Blind, Multicenter Phase 3 Trial of BMS-986489 (BMS-986012+Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide vs Atezolizumab in Combination With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).

The Purpose of the Study is to Compare the Efficacy and Safety of BMS-986489 (Anti-fucosyl-GM1+ Nivolumab Fixed Dose Combination) in Combination with Carboplat…

Extensive-Stage Small Cell Lung Cancer

Estimated

~$10 – $7,500

Bristol-Myers SquibbNCT06646276

Phase 3

A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Investigate the Efficacy and Safety of Once-Daily Oral Orforglipron Compared With Placebo in Individuals With Overweight at Risk of Development of Obesity-Related Complications or Progression to Class 1 Obesity

This study will evaluate the efficacy and safety of orforglipron in participants with overweight and assess whether it helps reduce the future risk of obesity-…

OverweightPrediabetic StatePrehypertension+1 more

Estimated

~$10 – $7,500

Eli Lilly and CompanyNCT07794579

Observational

The Impact of a Culturally-based Live Music Intervention on the Metabolites and Metabolic Pathways Associated With Chronic Stress and the Risk of Pre-term Birth in Black Women

This study will test a music intervention (MI) versus a sham control (SC) arm which only includes a verbal intervention, to determine if the effects of the mus…

Preterm Birth

Estimated

~$10 – $6,250

Columbia UniversityNCT05945264

Phase 1

Phase 1 Trial of CA-4948 in Combination With Pembrolizumab to Overcome Resistance to PD-1/PD-L1 Blockade in Metastatic Urothelial Cancer

This phase I trial tests the safety, side effects, best dose, and effectiveness of emavusertib (CA-4948) in combination with pembrolizumab in treating patients…

Metastatic Urothelial CarcinomaUnresectable Urothelial Carcinoma

Estimated

~$10 – $5,625

National Cancer Institute (NCI)NCT06439836

Phase 1

Phase 1B/2A Study of CTO1681 for the Prevention and Treatment of Cytokine Release Syndrome in Patients Receiving Chimeric Antigen Receptor T-Cell Therapy

This is an interventional study to evaluate the use of CTO1681 in preventing or reducing CAR T-cell-induced toxicities like cytokine release syndrome (CRS). Th…

Cytokine Release Syndrome

Estimated

~$10 – $8,750

CytoAgents, Inc.NCT05905328

Phase 1

A Phase 1 Open-Label, First-in-Human Trial of Oral MBQ-167 as Single Agent in Participants With Advanced Breast Cancer

A Phase 1, open-label, dose-escalation clinical trial of MBQ-167 in participants with advanced Breast Cancer for whom Standard of Care (SOC) has failed or has …

Breast CancerBreast NeoplasmBreast Cancer Stage IV

Estimated

~$10 – $8,750

MBQ PharmaNCT06075810

An International Observational Registry Study to Further Describe Long-term Safety and Effectiveness of Palovarotene in Patients With Fibrodysplasia Ossificans Progressiva (FOP)

The participants in this registry study will have fibrodysplasia ossificans progressiva (FOP). FOP is an ultra-rare, severely disabling disease characterized …

Fibrodysplasia Ossificans Progressiva

Phase II Prospective Evaluation of Desmopressin Stimulation Test Performance in ACTH-dependent Cushing s Syndrome

Background: Cushing syndrome (CS) is a set of diseases that develop when the body produces too much adrenocorticotropic hormone (ACTH). ACTH stimulates the pr…

Cushing Syndrome

Estimated

~$10 – $5,625

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NCT06635629

An Exploratory Study of the Genetics, Pathophysiology, and Natural History of Autoinflammatory Diseases

This study is designed to explore the genetics and pathophysiology of diseases presenting with intermittent fever, including familial Mediterranean fever, TRAP…

Familial Mediterranean Fever (FMF)AutoinflammationPeriodic Fever+4 more

Estimated

~$10 – $675

National Human Genome Research Institute (NHGRI)NCT00001373

Host Response to Infection and Treatment in Leishmania Infection of Humans

Patients admitted on this protocol must have an active Leishmania infection. The major objectives of the protocol are to diagnose and classify the Leishmania i…

KinetoplastidSkin Diseases, ParasiticParasitic Diseases+2 more

Estimated

~$10 – $675

National Institute of Allergy and Infectious Diseases (NIAID)NCT00344188

Phase 2

Phase II Randomized Controlled Trial of Biologically Guided Stereotactic Body Radiation Therapy in Oligoprogressive Non-Small Cell Lung Cancer, Melanoma, and Renal Cell Carcinoma

This phase II trial tests the safety of positron emission tomography (PET) guided stereotactic body radiation therapy (SBRT) and how well it works to treat non…

Lung Non-Small Cell CarcinomaMalignant Solid NeoplasmMelanoma+1 more

Estimated

~$10 – $6,250

City of Hope Medical CenterNCT05830058

Observational

Pilot Study to Evaluate the Feasibility of High Fiber Program in Patients Undergoing Allogeneic Hematopoietic Cell Transplant (HCT)

This clinical trial studies whether the High Fiber Program can be used to increase fiber intake in patients undergoing allogeneic hematopoietic cell transplant…

Hematopoietic and Lymphatic System Neoplasm

Estimated

~$10 – $6,250

City of Hope Medical CenterNCT07664670