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A Pilot Study to Evaluate the Safety and Tolerability of Baricitinib in Patients With Job s Syndrome With Lupus-like Disease and/or Atopic Dermatitis

Background: Autosomal dominant hyper-IgE syndrome (HIES), also called Job syndrome, is a genetic disorder that affects the immune system. It can cause skin an…

Hyper IgE Syndrome From STAT3 MutationJob s SyndromeHIES+2 more

Estimated

~$150 – $2,700

Actual pay is set by the research site.

National Institute of Allergy and Infectious Diseases (NIAID)NCT07262983

Phase 1

A Phase 1 Study of Oral Cedazuridine and Decitabine Combination (ASTX727, NSC# 820631) and Filgrastim as Maintenance Therapy Post-Hematopoietic Stem Cell Transplant in Children With High-Risk Acute Myeloid Leukemia

This phase I trial tests the safety, side effects, and best dose of ASTX727 and filgrastim for the treatment of children with high risk acute myeloid leukemia …

Acute Myeloid Leukemia Post Cytotoxic TherapyRecurrent Acute Myeloid LeukemiaRefractory Acute Myeloid Leukemia

Estimated

~$150 – $2,700

Actual pay is set by the research site.

National Cancer Institute (NCI)NCT07012044

Phase 2

Novel Regenerative Therapeutic in Chronic Complex TBI

This study will determine if allopregnanolone (ALLO) improves depression and pain symptoms in patients who have a history of mild traumatic brain injury (TBI) …

Traumatic Brain Injury (TBI)

Estimated

~$75 – $1,800

Actual pay is set by the research site.

VA Office of Research and DevelopmentNCT04003285

Phase 3

SERAFA-1: A Single Arm, Open Label, Multicentre, Phase IIIb Study Of Camizestrant Plus Ribociclib in 1st Line Treatment of ER Positive, HER2-negative Advanced Breast Cancer Patients

The purpose of this study is to investigate the efficacy, safety, and tolerability of camizestrant in combination with ribociclib in patients with ER+ HER2- BC…

ER-Positive HER2-Negative Breast Cancer

Estimated

~$50 – $2,250

Actual pay is set by the research site.

AstraZenecaNCT07647328

Phase 4

Fibrinogen in Liver Transplant Subjects (FITS)

The study is a prospective, multi-centered, unblinded, randomized controlled pilot study. The primary objective is to compare functional hemostatic capacity of…

Liver Transplant Surgery

Estimated

~$25 – $1,500

Actual pay is set by the research site.

Trauma Hemostatis and Oxygenation Research (THOR) NetworkNCT07265843

Phase 2

A Phase 2 Study of Toripalimab in Combination With Cisplatin and Docetaxel (PDT) for Induction Therapy in Locally Advanced Head and Neck Squamous Cell Carcinoma

This research study is being done to assess the safety and tolerability of toripalimab in combination with cisplatin and docetaxel (PDT) induction therapy for …

Squamous Cell CarcinomaHead and Neck Cancer Squamous Cell CarcinomaHead and Neck Cancer

Estimated

~$75 – $2,000

Actual pay is set by the research site.

Massachusetts General HospitalNCT07214987

Phase 2

A Phase 2, Randomized, Double-blind, Placebo-controlled, Parallel Group Study to Evaluate Efficacy, Safety, and Tolerability of HM15275 for 36 Weeks in Subjects With Type 2 Diabetes Mellitus

This study is a Phase 2 clinical trial to evaluate the efficacy, safety, and tolerability of HM15275 in subjects with type 2 diabetes mellitus over 36 weeks.

Type 2 Diabetes MellitusT2DM

Estimated

~$75 – $2,800

Actual pay is set by the research site.

Hanmi Pharmaceutical Company LimitedNCT07527650

Phase 3

A Phase III, Multicentre, Randomised Controlled Study to Evaluate the Efficacy and Safety of AZD2265 (FPI-2265) ²²⁵Ac-PSMA-I&T Compared With Standard of Care in Patients With PSMA-positive Metastatic Castration-resistant Prostate Cancer (VECTRA-01)

The intention of the study is to demonstrate superiority of AZD2265 relative to standard of care treatments by assessment of radiographic progression-free surv…

Metastatic Castration-resistant Prostate Cancer

Estimated

~$50 – $2,250

Actual pay is set by the research site.

AstraZenecaNCT07611110

Olfactory Function and Model-based Behavior in People Living With HIV and SUD

Background: Human immunodeficiency virus (HIV) infection can affect areas of the brain that control thinking ability. These same areas of the brain also contr…

HIVSubstance Use Disorder

Estimated

~$10 – $675

Actual pay is set by the research site.

National Institute on Drug Abuse (NIDA)NCT07637669

Paradoxical Tuberculosis Reactions in Patients Without HIV Infection

Background: Most people with tuberculosis (TB) feel better after starting treatment. But for some people, the opposite happens. They may feel better at first,…

Tuberculosis

Estimated

~$10 – $675

Actual pay is set by the research site.

National Institute of Allergy and Infectious Diseases (NIAID)NCT04052022

Phase 3

A Phase 3, Randomized, Open-label Study of Sacituzumab Tirumotecan (MK-2870) Versus Investigator's Choice of Non-platinum Chemotherapy in Participants With Pretreated Locally Advanced/Metastatic Urothelial Carcinoma

Researchers are looking for new ways to treat locally advanced or metastatic urothelial cancer (UC). Current treatments for locally advanced or metastatic UC i…

Bladder Cancer

Estimated

~$50 – $2,100

Actual pay is set by the research site.

Merck Sharp & Dohme LLCNCT07419295

Observational

Impact of Treatment Intensity on Survival, Quality of Life, and Resource Utilization in Medically Less Fit Adults With Acute Myeloid Leukemia or High-Grade Myeloid Neoplasms: A Randomized Pilot Study

This clinical trial studies whether less fit adults with acute myeloid leukemia (AML) or myeloid neoplasms are willing to let a computer program decide (random…

Acute Leukemia of Ambiguous LineageAcute Myeloid LeukemiaMyeloid Neoplasm

Estimated

~$10 – $750

Actual pay is set by the research site.

Fred Hutchinson Cancer CenterNCT07094750