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Sleep Promotion Among Children Newly Diagnosed With Essential Hypertension

Determine the effectiveness and feasibility of a mobile health sleep extension approach in the pediatric nephrology setting, to increase sleep duration and red…

Insufficient SleepHypertension

Estimated

~$10 – $6,250

Children's Hospital of PhiladelphiaNCT06642246

Phase 1

The Low-Down on Methamphetamine Isomers: Prevalence and Pharmacology in Humans

This study is being done to understand the metabolism and impairment profile of methamphetamine (meth). Meth exists as two chemical structures that are mirror …

Methamphetamine

Estimated

~$10 – $6,250

University of Wisconsin, MadisonNCT06746831

Phase 1

A Phase 1 Study of JNJ-87189401 (PSMA-CD28 Bispecific Antibody) Combined With JNJ-78278343 (KLK2-CD3 Bispecific Antibody) for Advanced Prostate Cancer

The purpose of Parts 1, 2A, and 2B of the study is to determine the recommended regimen for Phase 2 (RP2Rs) of combination of JNJ-87189401 with JNJ-78278343 an…

Prostatic Neoplasms

Estimated

~$10 – $8,750

Janssen Research & Development, LLCNCT06095089

Phase 3

A Phase 3, Randomized, Double-blind, and Active-controlled Multicenter Study to Evaluate the Efficacy and Safety of JNJ-78934804 in Participants With Moderately to Severely Active Crohn's Disease

The purpose of this study is to assess how well JNJ-78934804 works (efficacy) and how safe it is (safety) as compared to guselkumab at Week 48 in participants …

Crohn Disease

Estimated

~$10 – $8,750

Janssen Research & Development, LLCNCT07577843

Observational

A Single-center Randomized Controlled Trial Evaluating Whether Adding Fundal Mucosal Ablation (FMA) to Standard Endoscopic Sleeve Gastroplasty (ESG) Leads to Greater Weight Loss, Improved Obesity-related Comorbidities, and Better Metabolic and Hormonal Outcomes Compared With ESG Alone in Adults With Obesity.

The ENLIGHT Trial is a single-center, randomized controlled trial evaluating whether adding fundal mucosal ablation (FMA) to endoscopic sleeve gastroplasty (ES…

ObesityObesity (Body Mass Index >30 kg/m2)

Estimated

~$10 – $6,250

West Virginia UniversityNCT07792226

Familial Inflammatory Bowel Disease Early Risk (Fiber) Study

Brief Summary The aim of the FIBER study is to identify potential triggers associated with the later development of IBD (inflammatory bowel disease) based on …

Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis)Crohn Disease (CD)Ulcerative Colitis (UC)

Estimated

~$10 – $750

Seattle Children's HospitalNCT07791862

Observational

CLEAR-LUNG (Community-Level Effectiveness to Advance Reach in Lung Cancer Screening)

The long-term objective is to improve lung cancer screening uptake among screening-eligible Black adults and thereby reduce the population burden of late-stage…

Lung Cancer

Estimated

~$10 – $7,500

Hackensack Meridian HealthNCT07792824

Phase 1

A Phase 1 Study of JNJ-87890387, an Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 3 (ENPP3) x CD3 Bispecific Antibody, for Advanced Solid Tumors

The purpose of this study is to determine safety and recommended phase 2 dose(s) (RP2Ds) of JNJ-87890387 and to determine the safety of JNJ-87890387 at the RP2…

NeoplasmsAdvanced Solid Tumors

Estimated

~$10 – $8,750

Janssen Research & Development, LLCNCT06178614

RRA-18896: An Observational Study to Assess the Long-term Safety of Ustekinumab Versus Other Biologic Therapies Among Patients With Crohn's Disease: A New-User Cohort Study Using the Department of Defense Electronic Health Records Database

The purpose of this study is to estimate and compare the incidence of overall malignancy, serious infection, and opportunistic infections between new users of …

Crohn DiseaseColitis, Ulcerative

Estimated

~$10 – $1,050

Janssen Scientific Affairs, LLCNCT04372108

Tissue Procurement and Natural History Study of Patients With Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Extrapulmonary Small Cell Cancer, Pulmonary Neuroendocrine Tumors, and Thymic Epithelial Tumors

Background: \- Lung cancer is the leading cause of cancer-related death worldwide. It causes more than one million deaths every year. Researchers want to gath…

Non-Small Cell Lung CancerSmall Cell Lung CancerExtrapulmonary Small Cell Cancer+2 more

Estimated

~$10 – $675

National Cancer Institute (NCI)NCT02146170

PREcision MEDicine In Achalasia - A Multicenter Randomized Non-Inferiority Clinical Trial of Short Tailored POEM vs. Standard POEM for Non-Spastic Achalasia and A Multicenter Prospective Cohort Study of Long Tailored POEM for Spastic Esophageal Motility Disorders

The goal of this observational study is to learn about how the doctor decides how long to cut t the esophageal muscle during Per-Oral Endoscopic Myotomy (POEM)…

Type III AchalasiaEGJ Outflow Obstruction With Spastic/Hypercontractile FeaturesJackhammer Esophagus+1 more

Estimated

~$10 – $750

Northwestern UniversityNCT07293689

Phase 2

Odronextamab for Relapsed/Refractory Large B-Cell Lymphomas Before Definitive Lymphoma-Directed Therapies

This phase II trial tests the effectiveness of odronextamab given before chimeric antigen receptor T (CAR-T) cell therapy (bridging therapy) in patients with l…

Recurrent Diffuse Large B-Cell LymphomaRecurrent Diffuse Large B-Cell Lymphoma, Not Otherwise SpecifiedRecurrent Grade 3b Follicular Lymphoma+9 more

Estimated

~$10 – $6,250