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Evaluation of the Patient-Controlled Dispenser & Deactivator (PCDD) Generation 1 System for Oral Liquid Acetaminophen Delivery

This prospective randomized pilot study evaluates the feasibility, acceptability, and preliminary efficacy of the Patient-Controlled Dispenser and Deactivator …

Pain ManagementPostoperative Pain

Estimated

~$10 – $6,250

Yale UniversityNCT07765238

Phase 4

Endotype DIrected Treatment for OSA in Down Syndrome

Down syndrome is the most common genetic cause of intellectual disability. People with Down syndrome often have obstructive sleep apnea (OSA), a condition wher…

Obstructive Sleep Apnea (OSA)Down Syndrome

Estimated

~$10 – $6,250

University of ArizonaNCT07280468

Phase 2

A Phase 2/3 Multicenter, Open-label, Randomized, Active-Control Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (waveLINE-003)

The purpose of this Phase 2/3, randomized, multisite, open-label, dose confirmation, and expansion study is to evaluate the safety, and efficacy of zilovertama…

DLBCLDiffuse Large B-Cell Lymphoma

Estimated

~$10 – $8,750

Merck Sharp & Dohme LLCNCT05139017

Observational

QAIAx (AIhealth4U) - AI Smart Health Cities: Microcity Enclave Program (UPSTO App No(s). 64/074,526, 64/063,557, 64/105,164, 63/903,181, 63/729,428) is Frontier AI/AGI Public Health Trials Sandbox Framework That Provides Free Public Health Services to Registered and Sponsored Visitors/Occupants for RDT&E Under 28 U.S.C. 1498 (Classified as a PPA, OTA Under 10 U.S. Code 4001, 4022), Serving as a Global Intranet of Humans Resident Patients Among Multiple Enclave Communicates ("AI Microcities" or "Smart Health Cities") Living and Learning With AI Robotics for Non-medicinal Treatment.

BRIEF SUMMARY A. "What is the purpose of this study?" This study will test whether the "AI City Hall Project" (QAIAx), a quantum artificial intelligence (AI)…

Asperger's DisorderAsperger DisorderAutism Disorder+41 more

Phase 1

A Safety and Feasibility Study of NeuroNavigation-Guided Low Intensity Focused Ultrasound With Microbubbles to Enhance Nivolumab Delivery for the Treatment of Relapsed and Progressive Diffuse Midline Glioma and Other High Grade Brain Tumors

This is an open-label phase 1 safety and feasibility study evaluating a novel combination therapy for progressive and relapsed diffuse midline glioma (DMG) and…

Diffuse Midline Glioma or Diffuse Intrinsic Pontine GliomaHigh Grade GliomasMedulloblastoma Recurrent+3 more

Estimated

~$10 – $5,625

Children's National Research InstituteNCT07664176

Phase 1

Phase 1 Trial of Engineered HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

This study is a clinical trial to determine the safety of inoculating G207 (an experimental virus therapy) into a recurrent or refractory cerebellar brain tumo…

Neoplasms, BrainGlioblastoma MultiformeGlioblastoma of Cerebellum+30 more

Estimated

~$10 – $6,250

Mechanisms in Hepatic Lipid Metabolism in Alcohol Use Disorder: From Genomics, Transcriptomics to Metabolomics

Patients with hepatic steatosis due to alcohol will be offered liver biopsies when they enter a detoxification program. The first biopsy will occur in the firs…

Alcohol Use Disorder

Estimated

~$10 – $675

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NCT07191561

Phase 3

A Phase 3, Multicenter, 12-Week, Double Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Atogepant for the Preventive Treatment of Episodic Migraine in Pediatric Subjects 6-17 Years of Age.

A migraine is a moderate to severe headache on one side of the head. A migraine attack is a headache that may be accompanied by throbbing, nausea, vomiting, se…

A Prospective Adaptive Pilot Study of Serial Unstimulated Oocyte Retrieval and CAPA-IVM for Euploid Embryo Accumulation in Women With Robust Ovarian Reserve

This study is testing whether eggs can be collected from small follicles without using the usual ovarian stimulation medications. Participants will have up to …

Infertility

Estimated

~$10 – $7,500

Kevin DoodyNCT07801105

Phase 1

Effect of Tirzepatide on Markers of MASLD in Patients With Obesity: A Pilot Study

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is the most common cause of chronic liver disease worldwide and predominately affects individu…

MASLDObesity

Estimated

~$10 – $6,250

University of New MexicoNCT06934642

Observational

Evaluation of the Melanin-Adjusted Blood Oxygen Sensor (MABOS) in ICU Settings: Improving the Accuracy in Critical Conditions for Patients of Color

Purpose: Investigate the accuracy of the investigators' novel pulse oximeter across a broad range of skin-pigmentations and oxygen saturations. Participants: …

Hypoxemia

Estimated

~$10 – $6,250

University of North Carolina, Chapel HillNCT07799454

Phase 2

Phase II Trial of Enzalutamide and PDS01ADC in PET Positive Recurrent Prostate Cancer (pprPC) Without Testosterone Lowering Therapy

Background: Prostate cancer may return after treatment in 30,000 to 50,000 people each year. There is no clear best way to treat these people. Better treatmen…

Prostate CancerRecurrent Prostate CancerPET Positive

Estimated

~$10 – $5,625

National Cancer Institute (NCI)NCT06096870