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Estimating the Impact of a Multilevel, Multicomponent Intervention to Increase Uptake of HIV Testing and Biomedical HIV Prevention Among African-American/Black Gay, Bisexual and Same-gender Loving Men

The major goal of this study is to evaluate a multi-component, multilevel HIV prevention intervention that targets theoretically-informed and empirically-ident…

HIV TestingPrEP Uptake

Estimated

~$10 – $6,250

Columbia UniversityNCT06785376

Natural History of Glycosphingolipid Storage Disorders and Glycoprotein Disorders

Study description: This is a natural history study that will evaluate any patient with enzyme or DNA confirmed GM1 or GM2 gangliosidosis, sialidosis or galact…

Neurological RegressionMyoclonusCherry Red Spot+1 more

Estimated

~$10 – $675

National Human Genome Research Institute (NHGRI)NCT00029965

Observational

Integrating Values Based Communication in Heart Failure Management

Living with heart failure for adults over age 50 is hard. Older adults have to take many medicines to address heart failure and other health problems. That gro…

Heart Failure

Estimated

~$10 – $7,500

Abigail LatimerNCT07794930

Prospective Non-interventional, Phase IV Multicentre Study to Assess the Effectiveness, Safety and Tolerability of Elafibranor 80 mg/Day in Participants With Primary Biliary Cholangitis Receiving Treatment in a Real-world Setting.

This study will collect information from participants with Primary Biliary Cholangitis (PBC) as they use the drug elafibranor in real world setting. PBC is a …

Primary Biliary Cholangitis

Flyte System Transvaginal Mechanotherapy for Urinary Incontinence in Endometrial and Cervical Cancer Survivors: A Pilot Study

This clinical trial studies how well and how easy it is to use a device called Flyte in improving problems with bladder control (urinary incontinence) among en…

Cervical CarcinomaEndometrial CarcinomaOveractive Bladder+1 more

Estimated

~$10 – $6,250

Mayo ClinicNCT07662824

Observational

A Pilot Randomized Controlled Trial: Utilizing a Digital Inhaler Cap to Support for Remote Asthma Management in Adolescents With Intellectual and Developmental Disabilities

Correct use of daily medications containing inhaled corticosteroids is key for asthma control, yet children with intellectual and developmental disabilities (I…

Asthma in ChildrenIntellectual Disabilities (F70-F79)Developmental Disability+1 more

Estimated

~$10 – $6,250

Children's Hospital Los AngelesNCT07746921

Phase 3

A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Investigate the Efficacy and Safety of Once-Daily Oral Orforglipron Compared With Placebo in Individuals With Overweight at Risk of Development of Obesity-Related Complications or Progression to Class 1 Obesity

This study will evaluate the efficacy and safety of orforglipron in participants with overweight and assess whether it helps reduce the future risk of obesity-…

OverweightPrediabetic StatePrehypertension+1 more

Estimated

~$10 – $7,500

Eli Lilly and CompanyNCT07794579

Observational

The Impact of a Culturally-based Live Music Intervention on the Metabolites and Metabolic Pathways Associated With Chronic Stress and the Risk of Pre-term Birth in Black Women

This study will test a music intervention (MI) versus a sham control (SC) arm which only includes a verbal intervention, to determine if the effects of the mus…

Preterm Birth

Estimated

~$10 – $6,250

Columbia UniversityNCT05945264

Phase 1

Phase 1 Trial of CA-4948 in Combination With Pembrolizumab to Overcome Resistance to PD-1/PD-L1 Blockade in Metastatic Urothelial Cancer

This phase I trial tests the safety, side effects, best dose, and effectiveness of emavusertib (CA-4948) in combination with pembrolizumab in treating patients…

Metastatic Urothelial CarcinomaUnresectable Urothelial Carcinoma

Estimated

~$10 – $5,625

National Cancer Institute (NCI)NCT06439836

Phase 1

Phase 1B/2A Study of CTO1681 for the Prevention and Treatment of Cytokine Release Syndrome in Patients Receiving Chimeric Antigen Receptor T-Cell Therapy

This is an interventional study to evaluate the use of CTO1681 in preventing or reducing CAR T-cell-induced toxicities like cytokine release syndrome (CRS). Th…

Cytokine Release Syndrome

Estimated

~$10 – $8,750

CytoAgents, Inc.NCT05905328

Phase 1

A Phase 1 Open-Label, First-in-Human Trial of Oral MBQ-167 as Single Agent in Participants With Advanced Breast Cancer

A Phase 1, open-label, dose-escalation clinical trial of MBQ-167 in participants with advanced Breast Cancer for whom Standard of Care (SOC) has failed or has …

Breast CancerBreast NeoplasmBreast Cancer Stage IV

Estimated

~$10 – $8,750

MBQ PharmaNCT06075810

An International Observational Registry Study to Further Describe Long-term Safety and Effectiveness of Palovarotene in Patients With Fibrodysplasia Ossificans Progressiva (FOP)

The participants in this registry study will have fibrodysplasia ossificans progressiva (FOP). FOP is an ultra-rare, severely disabling disease characterized …

Fibrodysplasia Ossificans Progressiva

Estimated

~$10 – $1,125

IpsenNCT06089616