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A Phase 2/3 Randomized, Placebo-Controlled, Double-blind, Clinical Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Systemic Left Ventricular Systolic Dysfunction (VALOR)

This study aims to compare the efficacy of vericiguat versus placebo on change in n-terminal pro-brain natriuretic peptide (NTproBNP) from baseline to Week 16 …

Heart FailureLeft Ventricular Systolic Dysfunction

Estimated

~$10 – $8,750

Merck Sharp & Dohme LLCNCT05714085

Phase 2

A Phase 2, Open-Label, Parallel Cohort Study of Subcutaneous Amivantamab in Multiple Regimens in Patients With Advanced or Metastatic Solid Tumors Including EGFR-mutated Non-Small Cell Lung Cancer

The purpose of this study is to assess the anti-tumor activity and safety of amivantamab which will be administered as a co-formulation with recombinant human …

Carcinoma, Non-small-Cell Lung

Estimated

~$10 – $8,750

Janssen Research & Development, LLCNCT05498428

Phase 2

A Clinical Trial of Resistant Potato Starch for Gut MDRO Decolonization

Multidrug-resistant organisms (MDROs) cause serious infections that are difficult to treat, leading to increased morbidity and mortality, longer hospital stays…

Clostridium InfectionsMethicillin-resistant Staphylococcus Aureus (MRSA)Vancomycin-Resistant Enterococci+2 more

Estimated

~$10 – $5,625

VA Office of Research and DevelopmentNCT07792915

Phase 3

A Multicenter, Double-blind, Randomized, Placebo-controlled Study to Evaluate Efficacy and Safety of Seltorexant as Monotherapy in Adult and Elderly Participants With Major Depressive Disorder (MDD) and an Open-label Long-term Extension Treatment With Seltorexant

The main purpose of this study is to assess how well the study drug (JNJ-42847922) works (efficacy) compared with placebo in improving depressive symptoms in p…

Depressive Disorder, Major

Estimated

~$10 – $8,750

Janssen Research & Development, LLCNCT07573176

A Non-interventional Study of HLA-DRB1*04:01 Distribution in Adults With Recently Diagnosed Type 1 Diabetes (T1D)

This is a study to evaluate the HLA-DRB1\*04:01 genotype in adults that have been diagnosed with type 1 diabetes

Diabetes Mellitus, Type I

Estimated

~$10 – $1,050

GentiBio, IncNCT06860516

Phase 3

A Phase 3 Randomized, Double-blind, Placebo-controlled Study of Pasritamig (JNJ-78278343), a T Cell Engaging Agent Targeting Human Kallikrein 2, With or Without JNJ-87189401, a PSMA-CD28 Costimulatory Agent, Plus Best Supportive Care Versus Best Supportive Care for Late-line Metastatic Castration-resistant Prostate Cancer

The purpose of this study is to evaluate the overall survival (length of time from the start of study to date of death from any cause) for pasritamig (JNJ-7827…

Metastatic Castration-resistant Prostatic Neoplasms

Estimated

~$10 – $8,750

Janssen Research & Development, LLCNCT07164443

Phase 1

A Phase 1b/2, Open-Label Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer

The purpose of this study is to assess the anti-tumor activity of amivantamab as a monotherapy (Cohorts A, B, and C), to assess the recommended phase 2 combina…

Advanced or Metastatic Colorectal Cancer

Estimated

~$10 – $8,750

Janssen Research & Development, LLCNCT05379595

Longitudinal Prospective Study of Maternal and Child Nutrition in Arkansas - The Thrive Study

The investigators want to learn how women's diets may impact breastfeeding outcomes. This study will help the investigators learn more about how diet and socia…

Maternal NutritionInfant NutritionPediatric Nutrition+1 more

Estimated

~$10 – $750

Arkansas Children's Hospital Research InstituteNCT07477106

Phase 2

A Phase 2 Study Evaluating the Safety and Efficacy of Neoadjuvant Amivantamab in Combination With Lazertinib or Chemotherapy in Resectable EGFR-Mutated Non-Small Cell Lung Cancer

The purpose of this study is to assess the ability to slow down or stop the growth of cancer with amivantamab combined with either lazertinib or chemotherapy (…

Carcinoma, Non-Small-Cell Lung

Estimated

~$10 – $8,750

Janssen Research & Development, LLCNCT07586202

Observational

Sleep Promotion Among Children Newly Diagnosed With Essential Hypertension

Determine the effectiveness and feasibility of a mobile health sleep extension approach in the pediatric nephrology setting, to increase sleep duration and red…

Insufficient SleepHypertension

Estimated

~$10 – $6,250

Children's Hospital of PhiladelphiaNCT06642246

Phase 1

The Low-Down on Methamphetamine Isomers: Prevalence and Pharmacology in Humans

This study is being done to understand the metabolism and impairment profile of methamphetamine (meth). Meth exists as two chemical structures that are mirror …

Methamphetamine

Estimated

~$10 – $6,250

University of Wisconsin, MadisonNCT06746831

Phase 1

A Phase 1 Study of JNJ-87189401 (PSMA-CD28 Bispecific Antibody) Combined With JNJ-78278343 (KLK2-CD3 Bispecific Antibody) for Advanced Prostate Cancer

The purpose of Parts 1, 2A, and 2B of the study is to determine the recommended regimen for Phase 2 (RP2Rs) of combination of JNJ-87189401 with JNJ-78278343 an…

Prostatic Neoplasms

Estimated

~$10 – $8,750

Janssen Research & Development, LLCNCT06095089