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27,157 recruiting studies available now

A Phase 1/2 Study of Tegavivint (NSC#826393) in Children, Adolescents, and Young Adults With Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

This phase I/II trial evaluates the highest safe dose, side effects, and possible benefits of tegavivint in treating patients with solid tumors that has come b…

Colorectal CarcinomaEndometrial CarcinomaMelanoma+19 more

Estimated

~$10 – $7,500

Children's Oncology GroupNCT04851119

Phase 1

A Phase 1b/2 Study of Ropeginterferon Alfa-2b Added to Azacitidine in Newly Diagnosed MDS/AML (≥ 10% Blasts) With TP53 Mutations

To find the recommended dose of ropeginterferon alfa-2b in combination with azacitidine in patients with newly diagnosed MDS/AML with TP53 mutations. To learn …

RopeginterferonAlfa-2bAzacitidine+1 more

Estimated

~$10 – $6,250

M.D. Anderson Cancer CenterNCT07646821

Phase 2

Protocol Number: HJKC3-0003. Treatment Free Remission After Asciminib Based Therapy in Chronic Phase Chronic Myeloid Leukemia (CP-CML) Patients Who Relapsed After a Prior Attempt at TKI Discontinuation

This is a single arm phase II study that will enroll a minimum of 47 subjects with a maximum of 51. All patients will have a confirmed diagnosis of chronic pha…

Chronic Phase Chronic Myelogenous Leukemia

Estimated

~$10 – $6,250

Medical College of WisconsinNCT04838041

Phase 3

A Phase 3 Randomized Controlled Trial Comparing Open vs Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

This phase III trial compares the effect of open thoracic surgery (thoracotomy) to thoracoscopic surgery (video-assisted thoracoscopic surgery or VATS) in trea…

Metastatic Malignant Neoplasm in the LungMetastatic OsteosarcomaOsteosarcoma

Estimated

~$10 – $7,500

Children's Oncology GroupNCT05235165

Phase 1

A Phase 1, First-in-Human, Dose Escalation and Expansion Study to Evaluate the Safety and Tolerability of XmAb541 in Advanced Solid Tumors

The primary purpose of this study is to determine whether the investigational drug XmAb541 is safe and well tolerated, and to determine an optimal and safe dos…

Ovarian CancerEndometrial CancerGerm Cell Tumor+2 more

Estimated

~$10 – $8,750

Xencor, Inc.NCT06276491

Phase 2

REstoring Vascular and Insulin Function To Augment Anti-Amyloid Therapy in ALZheimer'ss Disease (REVITAA-ALZ): A Placebo-controlled Trial of Intranasal Insulin vs. Empagliflozin in Mild Cognitive Impairment (MCI) or Early Alzheimer's Disease (AD) Treated With Anti-Amyloid Targeting Therapy (Lecanemab or Donanemab)

The purpose of this study is to find out what effects (good and bad) the study medications (insulin or Empagliflozin) have on adults with mild memory impairmen…

Alzheimer Disease

Estimated

~$10 – $6,250

Wake Forest University Health SciencesNCT07756294

Patients' Preferences for Primary Immune Thrombocytopenia Treatment

This study aims to evaluate treatment preferences of patients with Primary Immune Thrombocytopenia (ITP) in the United States (US) by conducting a preference e…

Primary Immune Thrombocytopenia

Estimated

~$10 – $1,050

Novartis PharmaceuticalsNCT07786077

Observational

ACT-GEN (Adherence And Care Tracking In GENetic Cancer Syndromes)

To help people with high-risk cancer variants to follow cancer surveillance guidelines and lower their risk of developing the disease.

ACT-GENGenetic Cancer Syndromes

Estimated

~$10 – $6,250

M.D. Anderson Cancer CenterNCT07565467

Phase 1

A Molecularly Driven Phase 1b Dose Escalation and Dose Expansion Study of the DNA-PK Inhibitor Peposertib (M3814) in Combination With the ATR Inhibitor Tuvusertib (M1774)

This phase I trial tests the safety, side effects and best dose of peposertib (M3814) in combination with tuvusertib (M1774) in treating patients with solid tu…

Advanced Malignant Solid NeoplasmMetastatic Malignant Solid NeoplasmUnresectable Malignant Solid Neoplasm

Estimated

~$10 – $5,625

National Cancer Institute (NCI)NCT05687136

Phase 4

Evaluation of Speech and Voice Biomarkers in Association With Burnout

This project aims to explore how speech patterns and voice characteristics can be used to detect signs of burnout and stress in physicians.

BurnoutBurnout, Healthcare Workers

Estimated

~$10 – $6,250

Minneapolis Heart Institute FoundationNCT07780812

Observational

Effects of Flavonoid-rich Foods on Carbonyl Stress

This randomized crossover study will compare low- and high-flavonoid diets in healthy adults to identify flavonoid-derived biomarkers in urine and plasma. Usin…

Human HealthFlavonoidsCarbonyl Stress

Estimated

~$10 – $6,250

North Carolina Agriculture & Technical State UniversityNCT07767149

Phase 4

Investigator-led Observational Clinical Research Project Evaluating the Impact of the ReFeel for Digital Nerve Injuries.

This is an Investigator Led single-center, Prospective and Observational, Clinical Research Project. The specific aim of this study is to test/observe the safe…

Digital Nerve InjuryNerve Reconstruction

Estimated

~$10 – $8,750

OrthoCarolina Research Institute, Inc.NCT07524465