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26,914 recruiting studies available now

Evaluation of C-arm Photon Counting Detector Cone Beam CT (PCD-CBCT) for Image-Guided Interventions

The overarching objective of the project is to develop a new C-arm interventional x-ray imaging platform that integrates both a photon counting detector and a …

Imaging

Estimated

~$10 – $750

University of Wisconsin, MadisonNCT07092553

Phase 1

A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single and Multiple Dose Escalation Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BLKR201 in Healthy Adult Participants

The goal of this clinical trial is to learn if BLKR201 is safe in healthy adults. Researchers will also learn how the body absorbs and processes BLKR201 and ho…

Healthy

Estimated

~$10 – $8,750

Formation Bio, Inc.NCT07501039

Observational

A Mobile Text Approach to Measurement and Feedback for Wraparound Care Coordination

This SBIR Phase II proposal will fully develop and test the acceptability, feasibility, and efficacy of a novel measurement and feedback system, SMART-Wrap, ta…

Mental Health ServicesMobile TechnologiesTechnology Development

Estimated

~$10 – $7,500

3-C Institute for Social DevelopmentNCT07300930

Phase 1

KEYMAKER-U01 Substudy 01F: A Phase 1b/2 Umbrella Study With Rolling Arms of Investigational Agents for Previously Treated Participants With Advanced or Metastatic Nonsquamous Non-small Cell Lung Cancer (NSCLC) With KRAS G12C Mutations

Researchers want to learn if MK-1084, the study medicine, can treat advanced or metastatic non-squamous NSCLC. MK-1084 is a targeted therapy, which is a treatm…

Lung Neoplasm Malignant

Estimated

~$10 – $8,750

Merck Sharp & Dohme LLCNCT07286149

Phase 2

Phase II Trial of SMO/ AKT/ NF2/CDK Inhibitors in Progressive Meningiomas With SMO/ AKT/ NF2/CDK Pathway Mutations

This phase II trial studies how well vismodegib, focal adhesion kinase (FAK) inhibitor GSK2256098, and capivasertib work in treating patients with meningioma t…

Intracranial MeningiomaRecurrent MeningiomaNF2 Gene Mutation

Estimated

~$10 – $6,250

Alliance for Clinical Trials in OncologyNCT02523014

Observational

Right Ventricular Pacing to Treat Right Ventricular Failure: A Single Arm Hemodynamic Study

In pulmonary arterial hypertension (PAH), progressive pulmonary vascular remodeling leads to supraphysiologic right ventricular (RV) afterload. Pharmacologic t…

Pulmonary Artery HypertensionRight Ventricular Dysfunction

Estimated

~$10 – $5,625

University of California, San FranciscoNCT04194632

Phase 2

An Open Label, Non-Randomized, Multi-Center Pilot Dose-Expansion Study of Low Dose Post-Transplant Cyclophosphamide/Tacrolimus/Ruxolitinib for GVHD Prophylaxis in Myeloablative Allogeneic Peripheral Blood Stem Cell Transplantation

This is an open label, non-randomized, multicenter, pilot, dose expansion study of low dose post-transplant cyclophosphamide (25 mg/kg on Days +3 and +4)/tacro…

LeukemiaMyelodysplasiaChronic Myelomonocytic Leukemia

Estimated

~$10 – $7,500

Hannah Choe, MDNCT07249346

Phase 2

A Phase 2b, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Two-Part Study to Evaluate the Efficacy and Safety of Tonlamarsen in Participants With a Recent Hospitalization and a Concurrent Episode of Acute Severe Hypertension

The purpose of this study is to evaluate the blood pressure-lowering effect of tonlamarsen in adult participants who were recently hospitalized and concurrentl…

HypertensionAcute Severe HypertensionHypertensive Emergency+1 more

Estimated

~$10 – $8,750

Kardigan, Inc.NCT07511361

Natural History and Biospecimen Acquisition Study for Children and Adults With Rare Solid Tumors

Background: Approximately 150 cases of cancer per one million per year are considered rare cancers. While all tumors originate from genetic changes, a small p…

Malignant Solid TumorsOther Neoplasms Solid TumorsPediatric Solid Tumor+2 more

Estimated

~$10 – $675

National Cancer Institute (NCI)NCT03739827

Observational

PAGODA: Randomized Trial of a Proactive Graduated Dose Modification Algorithm for FOLFOX Chemotherapy to Prevent Unplanned Delays

This study seeks to learn whether using the PAGODA algorithm to guide chemotherapy dosing will lower the chance of unplanned delays during chemotherapy for can…

Ampulla of Vater CarcinomaAppendix CarcinomaCarcinoma of Unknown Primary With Gastrointestinal Profile+7 more

Estimated

~$10 – $6,250

Alliance for Clinical Trials in OncologyNCT07283939

Phase 1

A Phase 1, Randomized, Double-Blind, Comparator-Controlled Dose-Escalation Study to Evaluate the Safety, Tolerability, and Immunogenicity of V132 in Healthy Older Participants

The goal of this study is to learn about the safety and immune response to the V132 vaccine in healthy older adults.

Healthy

Estimated

~$10 – $8,750

Merck Sharp & Dohme LLCNCT07712575

Phase 3

Randomized, Open-Label Study of the Bria-IMT Regimen and Check Point Inhibitor vs Physicians' Choice in Advanced Metastatic Breast Cancer.

This is a multicenter randomized, open label study to evaluate overall survival with the Bria-IMT regimen in combination with Checkpoint Inhibitor \[Retifanlim…

Breast CancerMetastatic Breast CancerBreast Neoplasm+2 more

Estimated

~$10 – $8,750

BriaCell Therapeutics CorporationNCT06072612