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A Pilot Study to Evaluate the Safety and Tolerability of Baricitinib in Patients With Job s Syndrome With Lupus-like Disease and/or Atopic Dermatitis

Background: Autosomal dominant hyper-IgE syndrome (HIES), also called Job syndrome, is a genetic disorder that affects the immune system. It can cause skin an…

Hyper IgE Syndrome From STAT3 MutationJob s SyndromeHIES+2 more

Estimated

~$150 – $2,700

Actual pay is set by the research site.

National Institute of Allergy and Infectious Diseases (NIAID)NCT07262983

Phase 1

Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Exosome Intranasal Instillations for the Treatment of Stroke

This trial will study the safety and efficacy of intranasal instillation of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell…

Stroke

Estimated

~$150 – $3,000

Actual pay is set by the research site.

The Foundation for Orthopaedics and Regenerative MedicineNCT05158101

Amyloid PET Imaging in the Baltimore Longitudinal Study of Aging (BLSA)

Background: Some people experience cognitive decline as they age. That is, they lose memory, problem-solving, and other mental abilities. Amyloids are groups …

Aging

Estimated

~$10 – $675

Actual pay is set by the research site.

National Institute on Aging (NIA)NCT07099053

MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study

This prospective longitudinal study will compare incidence rates of Medicare beneficiary surgical and minimally invasive intervention post index procedure, as …

Lumbar Spinal Stenosis

Estimated

~$10 – $1,125

Actual pay is set by the research site.

Stryker InstrumentsNCT03072927

Observational

The Cardiometabolic Impact of Non-Nutritive Sweeteners in Young Adults With Type 1 Diabetes

This project will apply a novel non-nutritive sweetener (NNS) dietary assessment tool with measurement of circulating NNS levels in a pediatric population, all…

Non-Nutritive SweetenerType 1 Diabetestype1diabetes+1 more

Estimated

~$10 – $750

Actual pay is set by the research site.

Medical College of WisconsinNCT07434544

Phase 2

A Phase 2/3, Multicenter, Randomized, Double-Blind Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Oral Ozanimod (RPC1063) in Pediatric Subjects With Moderately to Severely Active Ulcerative Colitis With an Inadequate Response to Conventional Therapy

The purpose of this study is to evaluate the effectiveness and safety of ozanimod (RPC1063) in achieving and maintaining clinical remission. Ozanimod will be a…

Colitis, Ulcerative

Estimated

~$75 – $3,000

Actual pay is set by the research site.

Bristol-Myers SquibbNCT05076175

Phase 3

A Phase 3, Randomized, Double-mask, Placebo-controlled Study With Open-label Extension to Evaluate the Efficacy and Safety of Linsitinib in Participants With Moderate to Severe Active Thyroid Eye Disease (TED)

The goal of this clinical trial is to evaluate the efficacy, safety, and tolerability of linsitinib in participants with moderate to severe Thyroid Eye Disease…

Thyroid Eye Disease, TEDGraves Orbitopathy

Estimated

~$50 – $2,100

Actual pay is set by the research site.

Sling Therapeutics, Inc.NCT07753603

Phase 3

A Phase IIIb, Single-Arm, Open-Label Study Evaluating Adherence, Tolerability, and Patient Reported Outcomes (PRO) of Giredestrant in Patients With ER+/HER2- Early Breast Cancer Who Are Intolerant to Adjuvant Aromatase Inhibitor Therapy

The purpose of this study is to understand treatment adherence and patient-reported outcomes of switching to giredestrant due to prior aromatase inhibitor (AI)…

Early Breast Cancer

Estimated

~$50 – $2,100

Actual pay is set by the research site.

Genentech, Inc.NCT07541079

Phase 1

A Randomized, Double-Masked, Placebo-Controlled, Single Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ETHY-001

The primary objective of study is to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of ETHY-001 in healthy volunteers and partici…

Thyroid Eye Disease (TED)Graves' DiseaseEye Diseases, Hereditary+11 more

Estimated

~$500 – $10,500

Actual pay is set by the research site.

Ethyreal Bio, Inc.NCT07885605

Phase 1

A Phase 1b, Open-label, Pilot Study of CLN-978 for the Treatment of Moderate to Severe Systemic Lupus Erythematosus (SLE)

Phase 1b, open-label study of CLN-978 administered subcutaneously in patients with Moderate to Severe Systemic Lupus Erythematosus (SLE).

SLESLE (Systemic Lupus)

Estimated

~$150 – $4,200

Actual pay is set by the research site.

Cullinan Therapeutics Inc.NCT06613360

Psychotherapy for Irritability in Youth: Comparing Active Treatment to Non-Active Psychoeducation Supportive Psychotherapy

Background: Irritability is defined as proneness to anger that may impair a person's ability to function. It is a common reason for why some children need men…

IrritabilityDisruptive Mood Dysregulation DisorderOppositional Defiant Disorder+1 more

Estimated

~$10 – $675

Actual pay is set by the research site.

National Institute of Mental Health (NIMH)NCT07640802

Observational

Improving Health-Related Quality of Life Communication Between AYA Oncology Patients and Clinicians: A Patient-Centered Intervention

The overarching goal is to develop and demonstrate proof-of-concept of ReSPECT (Reproductive and Sexual Health Patient Education and Communication Tool), a mul…

Pediatric CancerAdolescent and Young Adult Cancer

Estimated

~$10 – $750

Actual pay is set by the research site.

Connecticut Children's Medical CenterNCT06982066