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A Phase 1/2, Open-label Study of Oral S241656 (BDTX-4933) as Monotherapy and in Combination With Other Anti-Cancer Therapies in Patients With KRAS, BRAF and Other Selected RAS/MAPK Mutation-Positive Malignancies

BDTX-4933-101 is a first-in-human, open-label, Phase 1/2 dose escalation, dose optimization and expansion study designed to evaluate the safety and tolerabilit…

Non-small Cell Lung CancerHistiocytic NeoplasmHistiocytosis+29 more

Estimated

~$150 – $4,500

Actual pay is set by the research site.

Institut de Recherches Internationales ServierNCT05786924

Phase 2

Systems Biology of a mRNA Vaccine Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Given Via Intradermal (ID) Injection Using Tropis Needle-Free Injection System (NFIS) or Intramuscular (IM) Injection Using Needle and Syringe

The purpose of this study is to determine if immune responses differ when the mRNA COVID-19 vaccine is given through different delivery methods, including a ne…

Evaluate Immune Responses Following mRNA COVID-19 Vaccine Administration Through Different Delivery Routes in Healthy VolunteersSARS CoV-2

Estimated

~$75 – $2,800

Actual pay is set by the research site.

PharmaJet, Inc.NCT06919796

Phase 1

Assessment of 11C-JMJ-129 for Imaging PDE4D in Brain and Whole Body of Healthy Volunteers

Background: PDE4D is a protein in the body that plays a role in thinking and depression. This protein may play a major role in disorders such as Alzheimer dis…

Healthy

Estimated

~$500 – $6,750

Actual pay is set by the research site.

National Institute of Mental Health (NIMH)NCT06874205

Phase 2

An Open Label Clinical Trial to Evaluate the Efficacy and Safety of PRAX-628 in Adult Patients With Focal Onset or Primary Generalized Tonic-Clonic Seizures

Focal Onset SeizurePrimary Generalized Epilepsy

Estimated

~$75 – $3,000

Actual pay is set by the research site.

Praxis Precision MedicinesNCT06908356

Observational

Intracalvarial Prefrontal Cortical Stimulation in Treatment-Resistant Depression

Chronic intracalvarial cortical stimulation is a minimally invasive method involving the neurosurgical placement of an electrode above the inner table of the s…

Depression Severe

Estimated

~$10 – $1,050

Actual pay is set by the research site.

Inner Cosmos IncNCT05393622

ViBandz Feasibility Study in the Neurological Pediatric Population

This is a single site, mixed methods, feasibility study of the ViBandz device at a Midwest pediatric tertiary care hospital in a physical and occupational ther…

PediatricsNeurologic DysfunctionVibration Therapy

Estimated

~$10 – $750

Actual pay is set by the research site.

Children's Mercy Hospital Kansas CityNCT07458568

Observational

HOBSCOTCH-CA (HOme-Based Self-management and COgnitive Training CHanges Lives in Brain CAncer)

The purpose of this study is to assess the ability of the home-based intervention, HOBSCOTCH-CA, to improve the quality of life and cognitive function in Servi…

Brain CancerBrain TumorBrain Neoplasms+9 more

Estimated

~$10 – $750

Actual pay is set by the research site.

Dartmouth-Hitchcock Medical CenterNCT06930846

Phase 1

REPEAT: RE-irradiation With a Partial brEast, Accelerated Technique: A Single-Center, Multi-site, Prospective, Phase I/II Clinical Trial

This study is to determine whether acute treatment-associated adverse events following breast re-irradiation with aPBI are acceptably low and to assess local c…

Breast Cancer Recurrent

Estimated

~$150 – $3,000

Actual pay is set by the research site.

Dartmouth-Hitchcock Medical CenterNCT07612254

A Multi-Modal Wearable Sensor for Early Detection of Cognitive Decline and Remote Monitoring of Cognitive-Motor Decline Over Time

This observational study will enroll approximately 100 participants evenly split by cognitive status (Cognitively Impaired vs Non-Cognitively Impaired), and in…

Mild Cognitive Impairment (MCI)Older Adults With Cognitive DeclineOlder Adults

Estimated

~$10 – $1,125

Actual pay is set by the research site.

BioSensicsNCT07780162

Phase 2

A Randomized Phase II Study of Tepotinib With or Without Ramucirumab in Participants With MET Exon 14 Skipping Positive Stage IV or Recurrent Non-Small Cell Lung Cancer (LUNG-MAP SUB-STUDY)

This phase II Expanded Lung-MAP treatment trial tests tepotinib with or without ramucirumab for the treatment of patients with advanced non-small cell lung can…

Recurrent Lung Non-Small Cell CarcinomaStage IV Lung Cancer AJCC v8

Estimated

~$75 – $3,000

Actual pay is set by the research site.

SWOG Cancer Research NetworkNCT06031688

Observational

Recovery From Post-Stroke Aphasia With rTMS Targeting the Anterior Temporal Lobe: Interhemispheric Activation Changes and Lesion-Connectome-Based Predictive Outcomes

This project aims to tailor repetitive Transcranial Magnetic Stimulation (rTMS) target to the clinical profile of post-stroke aphasia, specifically focusing on…

StrokeAphasia

Estimated

~$10 – $750

Actual pay is set by the research site.

University of South CarolinaNCT07608588

Phase 1

Phase I/II Study of Leflunomide in Combination With Decitabine for Treatment of Relapsed or Refractory (R/R) Myelodysplastic Syndromes (MDS)

The goal of this interventional clinical trial is to evaluate the safety and tolerability of leflunomide in combination with decitabine as treatment for patien…

Myelodysplastic Syndromes

Estimated

~$150 – $3,000

Actual pay is set by the research site.

West Virginia UniversityNCT06923488