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359 recruiting studies matching your filters

Evaluation of Fibrotic Disease Activity in Cardiopulmonary Disorders Using 18F-Fibroblast Activation Protein Inhibitor (18F-FAPI-74 PET/CT Imaging)

Background: Injury or diseases of the heart and lung can sometimes cause scar tissue (fibrosis) to build up in those organs. Current imaging scans can see thi…

Allogeneic Stem Cell TransplantationLung Allograft TransplantationInterstitial Lung Disease+3 more

Estimated

~$10 – $5,625

National Heart, Lung, and Blood Institute (NHLBI)NCT07613099

Observational

A Placebo-controlled, Double-blind, Safety and Experience Evaluation of IgG Binding Protein LT (BP-LT).

This study evaluates the safety and tolerability of the food ingredient IgG Binding Protein LT (BP-LT) when added to a daily diet. BP-LT is a stable protein in…

Safety and Tolerability in Healthy Volunteers

Estimated

~$10 – $7,500

Bactolife A/SNCT07824011

State Representation in Early Psychosis 2

This observational study will examine behavioral and electroencephalography measures related to state representation in individuals with early psychosis and he…

Early PsychosisPsychosisSchizophrenia+2 more

Estimated

~$10 – $750

University of MinnesotaNCT07834203

Natural History Study of Clinical and Biological Factors Determining Outcomes in Chronic Graft-Versus-Host Disease

Background: * Chronic graft-versus-host disease (cGVHD) is a multi-organ alloimmune and autoimmune disorder that occurs following allogeneic hematopoietic ste…

Chronic Graft vs. Host Disease

Estimated

~$10 – $675

National Cancer Institute (NCI)NCT00092235

Phase 2

An Open-label, Phase 1/2, Multicenter Study of Belumosudil in Children Aged 1 to <18 Years Requiring Systemic Treatment for Active Moderate-to-severe Chronic Graft Versus Host Disease (cGVHD)

This is an open-label, single group, Phase 1/2, 1-arm study for treatment of children aged 1 to \<18 years with active moderate-to-severe cGVHD that is refract…

Chronic Graft Versus Host Disease

Estimated

~$10 – $7,500

SanofiNCT07116031

Screening and Baseline Assessment of Patients With Abnormalities of Immune Function

This study will evaluate patients with abnormal immune function that results in recurrent or unusual infections or chronic inflammation. This may include inher…

Chronic Granulomatous Disease (CGD)X-Linked Severe Combined Immune Deficiency (XSCID)Leukocyte Adhesion Deficiency 1 (LAD)+1 more

Estimated

~$10 – $675

National Institute of Allergy and Infectious Diseases (NIAID)NCT00128973

Mapping On-Target Effects of Axatilimab in Human Chronic Graft-versus-Host Disease Skin: A Prospective Observational Mechanistic Study

Chronic graft-versus-host disease (cGVHD) is a condition that can develop after a stem cell transplant. It occurs when donor immune cells attack the body's tis…

Chronic Graft vs. Host DiseaseGVHDcGVHD+1 more

Estimated

~$10 – $750

Northwestern UniversityNCT07728708

Phase 1

A Trial to Evaluate Deoxyribonucleic) in BRAF (V-raf Murine Sarcoma Viral Oncogene Homolog B1)-Altered Glioma During Treatment With Plixorafenib Alone or With Retifanlimab

The investigators will evaluate the sensitivity of ctDNA from plasma and CSF at baseline (defined as C1D1) and over time in response to treatment with plixoraf…

BRAF V600E Mutation

Estimated

~$10 – $6,250

Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsNCT06610682

Phase 1

A Phase I Study of the Safety, Immunogenicity and Efficacy of a Tetravalent Dengue VLP Vaccine (VLPDEN-02) Against DENV-3 Challenge in Healthy Adults

This is a Phase 1, randomized, double-blind, placebo-controlled, dose escalation study. Forty-two flavivirus-naïve adults will be enrolled and will receive 3 a…

Randomised Clinical TrialDouble BlindDengue+2 more

Estimated

~$10 – $8,750

VLP TherapeuticsNCT07831473

Phase 4

A Phase 4, Open-Label Study to Evaluate the Efficacy of Valbenazine on Clinician- and Patient-Reported Outcomes in Patients With Tardive Dyskinesia (TD) Who Remain Symptomatic While on Deutetrabenazine or After Discontinuing Prior TD Treatment With a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor

This study will evaluate the efficacy of valbenazine on clinician- and patient-reported outcomes in participants with TD while receiving or after stopping a VM…

SchizophreniaSchizoaffective DisorderBipolar Disorder+2 more

Estimated

~$10 – $8,750

Neurocrine BiosciencesNCT07105111

Phase 3

A Master Protocol for a Phase 3, Randomized, Multicenter, Double-blind Study to Assess Stroke and Systemic Embolism Prevention With REGN7508 and REGN9933, Monoclonal Antibodies Against Factor XI, Versus Placebo in Participants With Atrial Fibrillation for Whom Oral Anticoagulation is Unsuitable (ROXI-INCLINE)

This study is researching 2 different experimental drugs called REGN7508 and REGN9933 (called "study drugs"). The study is focused on people who have atrial fi…

Atrial Fibrillation (AF)

Estimated

~$10 – $8,750

Regeneron PharmaceuticalsNCT07430956

Phase 2

Randomized Phase II Study of Belumosudil vs. Placebo for Preemptive Treatment of Chronic Graft Versus Host Disease

This phase II trial compares the effect of belumosudil to a placebo in treating patients with chronic graft versus host disease. Chronic graft versus host dise…

Chronic Graft Versus Host Disease

Estimated

~$10 – $6,250

Fred Hutchinson Cancer CenterNCT05996627