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24 recruiting studies matching your filters

PrOspective Non-interventional Study in Patients With Locally Advanced or Metastatic TRK Fusion Cancer Treated With Larotrectinib

In this observational study researcher want to learn more about the effectiveness of drug VITRAKVI (generic name: larotrectinib) and how well the drug is toler…

Locally Advanced or Metastatic Solid Tumor Harboring an NTRK Gene Fusion

Estimated

~$10 – $1,125

BayerNCT04142437

Blinded Reference Set for Multicancer Early Detection Blood Tests

This study collects blood and tissue samples from patients with cancer and without cancer to evaluate tests for early cancer detection. Collecting and storing …

Acute Lymphoblastic LeukemiaAcute Myeloid LeukemiaAnn Arbor Stage I Lymphoma+59 more

Phase 1

A Phase 1b/2a, Open-Label, Dose-Exploration Basket Study to Investigate the Safety and Tolerability of Subretinally Injected OPGx-BEST1 Administered in Patients With Either Autosomal-Dominant BEST1 Disease (Best Vitelliform Macular Dystrophy [BVMD]) or Autosomal-Recessive Bestrophinopathy (ARB)

The goal of this clinical trial is to learn if drug OPGx-BEST1 works to treat BVMD and ARB Bestrophinopathy. It will also learn about the safety of drug OPGx-B…

ARBBVMDAutosomal-Dominant Bestrophinopathy+1 more

Estimated

~$10 – $8,750

Opus Genetics, IncNCT07185256

Phase 1

A Phase 1 Randomized, Observer-blind, Placebo-controlled, Dose-escalation Clinical Trial to Evaluate the Safety and Immunogenicity of rVSV∆G-MARV-GP Vaccine in Adults in Good General Health

A Phase 1 Randomized, Observer Blind, Placebo-controlled, Dose-escalation and dose expansion Clinical Trial to Evaluate the Safety and Immunogenicity of rVSV∆G…

Marburg Virus Disease

Estimated

~$10 – $7,500

International AIDS Vaccine InitiativeNCT07425821

Phase 2

An Open-Label, Phase 2b, Global Multicenter Cohort Trial to Assess the Safety and Efficacy of Zipalertinib in Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer With Exon 20 Insertion and Uncommon/Single or Compound Epidermal Growth Factor Receptor Mutations.

The purpose of this study is to evaluate the safety, efficacy and pharmacokinetics (PK) of zipalertinib in participants with locally advanced or metastatic Non…

Advanced or Metastatic NSCLC Harboring Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion (ex20ins) Mutations

Estimated

~$10 – $8,750

Taiho Oncology, Inc.NCT05967689

Long-term Follow-up (LTFU) Study of Participants in Any iECURE Protocol Using an Investigational Product (IP)

This LTFU is being conducted to assess long-term safety and durability of response in participants dosed with IP in a parent protocol, and to collect longitudi…

Ornithine Transcarbamylase DeficiencyOrnithine Transcarbamylase Deficiency DiseaseUrea Cycle Disorders, Inborn

Estimated

~$10 – $1,050

iECURE, Inc.NCT06805695

Phase 2

A Clinical Trial of Resistant Potato Starch for Gut MDRO Decolonization

Multidrug-resistant organisms (MDROs) cause serious infections that are difficult to treat, leading to increased morbidity and mortality, longer hospital stays…

Clostridium InfectionsMethicillin-resistant Staphylococcus Aureus (MRSA)Vancomycin-Resistant Enterococci+2 more

Estimated

~$10 – $5,625

VA Office of Research and DevelopmentNCT07792915

Phase 2

Low Dose Mosunetuzumab for Indolent B-Cell Lymphoma

This phase II trial tests the safety, side effects and effectiveness of mosunetuzumab in treating patients with slow growing (indolent) B-cell lymphoma. Mosune…

Ann Arbor Stage II Follicular LymphomaAnn Arbor Stage II Marginal Zone LymphomaAnn Arbor Stage III Follicular Lymphoma+6 more

Estimated

~$10 – $6,250

University of WashingtonNCT06442475

Phase 1

Master Protocol for a Phase I/II Open-label Safety and Efficacy Study of LNP.UCD.ABE, a Lipid Nanoparticle-delivered Base Editing Therapy, in Patients With Urea Cycle Disorders Due to Variants Amenable to Corrective Editing by LNP.UCD.ABE

This is a single-site Phase 1/2 open-label umbrella clinical trial designed to evaluate the safety, tolerability, and efficacy of a single intravenous dose of …

Urea Cycle DisordersCarbamoyl-Phosphate Synthase I Deficiency

Estimated

~$10 – $7,500

Rebecca Ahrens-NicklasNCT07667387

Observational

Effects of Flavonoid-rich Foods on Carbonyl Stress

This randomized crossover study will compare low- and high-flavonoid diets in healthy adults to identify flavonoid-derived biomarkers in urine and plasma. Usin…

Human HealthFlavonoidsCarbonyl Stress

Estimated

~$10 – $6,250

North Carolina Agriculture & Technical State UniversityNCT07767149

Phase 2

A Phase 2 Study to Evaluate the Safety and Efficacy of Telisotuzumab Adizutecan for the Treatment of Subjects With Locally Advanced or Metastatic Solid Tumors That Harbor MET Amplification

Cancer is a condition where cells in a specific part of body grow and reproduce uncontrollably. The purpose of this study is to assess adverse events and chang…

Solid Tumors Harboring MET Amplification

Trial of Dexamethasone vs Placebo as an Adjunctive Therapy to Hyperbaric Oxygen Treatment HBO in Patients With Acute Carbon Monoxide Poisoning

Hyperbaric Oxygen Therapy (HBO) is routine treatment of carbon monoxide (CO) poisoning to prevent delayed neurological sequelae. This study looking to see if n…

Carbon Monoxide PoisoningCarbon Monoxide IntoxicationCarbon Monoxide Encephalopathy+1 more

Estimated

~$10 – $6,250

University of NebraskaNCT06574048