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Behavioral Intervention Development Core - Working Memory Digital Intervention in Aging
The goal of this clinical trial is to learn if engaging with an digital intervention may improve cognitive function. The main questions it aims to answer are: …
Aging, Beta Blockers, and Thermoregulatory Responses
This study will test the hypothesis that the drugs propranolol and metoprolol will result in greater increases in core body temperature during 3 hours of extre…
Multidimensional Predictive Modeling to Understand Mechanisms of Exercise Response Heterogeneity in Older Adults
Aging-related functional declines are thought to be caused by hallmark biological processes that ultimately manifest in physical, mental, and metabolic impairm…
ageWELL in the Community Together (aCT) Study
The aCT Study will develop, implement and evaluate a community health worker (CHW) integrated model of care delivery for older adults that is senior center bas…
Anabolic Versus Catabolic Skeletal Effects of Endurance or Resistance Exercise in Older Veterans
Adults are often encouraged to exercise to maintain or improve bone health. However, there is evidence that exercise does not always lead to increases in bone …
Angiotensin-(1-7) Cardiovascular Effects in Aging
Aging is an independent risk factor for developing hypertension and cardiovascular disease; however, the mechanisms underlying age-related cardiovascular disea…
Identifying Challenges to Healthy Aging in Persons With HIV Age 50 and Older
The primary objective of this study is to identify and characterize frailty and pre-frailty in persons age 50 and older living with human immunodeficiency viru…
Impact of Extreme Heat on Myocardial Blood Flow and Flow Reserve in Young and Older Adults
Extreme heat causes a disproportionate number of hospitalizations and deaths in older adults relative to any other age group. Importantly, many hospitalization…
Treating Balance Impairment of the Elderly With TMS-induced Brain Connectivity
The goal of this study is to learn if manipulating the brain using magnets works to treat balance impairment, a major cause of falls, in older adults with bala…
Pain in Athletes INtervention (PAIN): A Randomized Crossover Clinical Trial in Aging Former Athletes, Master's Athletes, and Nonathletes
The goal of this clinical trial is to determine how male and female former athletes experience pain and respond to moderate-intensity exercise (strength versus…
Neurocognitive Mechanisms Underlying Smartphone-Assisted Prevention of Relapse in Opioid Use Disorder
The proposed clinical trial would evaluate the use of smartphone applications ("apps", which have well-established efficacy in reducing cigarette and alcohol u…
Mechanisms Underlying Carbon Dioxide Induced Protein Efflux in Health and Traumatic Brain Injury
The current study tests whether different exposures to carbon dioxide (CO2) can safely result in the increased movement of proteins from the brain into the blo…