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Phase 2 Study of Apremilast in Women and Men With Alcohol Use Disorder
For this protocol, the investigators plan to collect data to evaluate apremilast (60mg/day) vs placebo in adults with Alcohol Use Disorders (AUD).
Preliminary Safety and Efficacy of Semaglutide and Naltrexone Combination Therapy for Alcohol Use Disorder
This human laboratory study will collect preliminary safety and efficacy data from a sample of participants enrolled in a 4-week in-patient treatment program f…
Effects of Ketogenic Diet on Alcohol Intoxication
The research study is being conducted to better understand the effects of ketosis on brain functioning and the acute effects of alcohol. Participants will be a…
Influence of Mavoglurant on Alcohol Craving and Drinking in Heavy Drinkers
The purpose of this research study is to find out about the effects of a drug called mavoglurant on alcohol consumption.
Better Experiences in Substance Treatment: A Brief Alcohol-Focused Intervention Tailored for Patients in Opioid Agonist Treatment
This study will help determine the feasibility and acceptability of a brief opioid-informed alcohol intervention in patients receiving prescribed buprenorphine…
Maternal Outcomes: Mood, Alcohol Use, and Depressive Symptoms (MOMS-AD Pilot Study)
This study aims to learn about depression and alcohol use in postpartum mothers and whether an intervention based on contingency management and problem-solving…
Influence of Orexin Antagonism on Motivation for Alcohol
This research will translate findings from preclinical research and provide the initial clinical evidence that orexin antagonism reduces motivation for alcohol…
Alcohol Treatment Outcomes Following Early vs. Standard Liver Transplant for Severe Alcoholic Hepatitis (SAH)
Given the severe consequences of alcohol relapse following liver transplantation for alcoholic hepatitis (AH-LT), it is critical to accurately identify alcohol…
Imaging PDE4B in People With Psychiatric Disorders With PET and the Radiotracer [18F]PF974
Imaging PDE4B in people with psychiatric disorders with PET and the radiotracer \[18F\]PF974
Development and Initial Testing of a Multi-Component Breath Alcohol-Focused Intervention for Young Adults, Stage 3
This is the third stage of a three-stage, NIH-funded study to develop and test a multi-modal intervention concerning blood/breath alcohol concentration for you…
Sex Differences in Risk for Alcohol Use Disorder: Neural and Hormonal Influences
The sex gap in alcohol consumption is closing rapidly, due to alarming increases among women. From 2002-2013, Alcohol Use Disorder (AUD) increased 84% for wome…
Guanfacine for Alcohol Use Disorder (AUD): a Telehealth Approach
The investigators assess whether guanfacine extended release (GXR; 3mg/d) compared with placebo (PBO) will attenuate drinking and drinking-related factors in N…