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Exogenous Tuning of Neural Oscillations as a Mode of Treatment in Post-stroke Aphasia
This study will assess the effects of transcranial alternating current stimulation (tACS) on language recovery after stroke as well as healthy language functio…
Neurocognitive Mechanisms of Sentence Production Impairment in Aphasia
The proposed research is relevant to public health because stroke is a leading cause of long-term disability among older adults and communication impairments r…
The Neurobiology of Two Distinct Types of Progressive Apraxia of Speech
The purpose of this study is to identify and distinguish two different types of Progressive Apraxia of Speech through clinical imaging and testing.
Precision Neuromodulation in Post-Stroke Aphasia Using TMS
The investigator proposes to examine the effects of excitatory transcranial magnetic stimulation (TMS) combined with semantic feature analysis (SFA) language t…
Genetic and MRI Biomarkers of Neuroplasticity Predict Aphasia Recovery and Phenotypes
Patients with stroke frequently suffer from aphasia, a disorder of expressive and/or receptive language, that can lead to serious health consequences, includin…
A Phase 2a Clinical Study of the P38 Alpha Kinase Inhibitor Neflamapimod in Patients With Primary Progressive Aphasia (PPA)
The goal of this exploratory study is to evaluate the effect of neflamapimod in participants with nonfluent variant primary progressive aphasia (nfvPPA). We ai…
Enhancing Language Function in Aphasia Using Behavioral Language Intervention
Aphasia is an acquired impairment of language, that commonly results from damage to language areas in the brain (typically the left side of the brain). This im…
Probing Language Processes Using Transcranial Magnetic Stimulation
This study will examine the effect of TMS on people with stroke and aphasia as well as healthy individuals.
Sequencing and Initiation in Speech Production: Investigating Speech Sequencing in Neurotypical Speakers, Persons Who Stutter, and Persons With Primary Progressive Aphasia
Persistent developmental stuttering affects more than three million people in the United States, and it can have profound adverse effects on quality of life. D…
Educational Support Group Program for Carepartners of Bilingual and Spanish-speaking Persons With Progressive Forms of Aphasia and for Persons With Progressive Forms of Aphasia
The current study aims to examine the benefits of an education/support group program for individuals with progressive aphasia (caused by various etiologies, di…
Personalized Transcranial Magnetic Stimulation and Constraint Induced Language Therapy to Treat Mild Post-Stroke Aphasia
The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with Speech-Language Therapy (SLT) is an effective treatmen…
Integrating Complementary Learning Principles in Aphasia Rehabilitation Via Adaptive Modeling (Sub-study 2: Adaptive Trial Scheduling)
Aphasia is a language disorder caused by stroke and other acquired brain injuries that affects over two million people in the United States and which interfere…