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Johns Hopkins All Children's HospitalNCT07455396

Phase 2

Azithromycin as Immunomodulation Among Children Hospitalized for Critical Asthma: A Prospective, Open-Label, Non-Randomized, Interventional Study With Parallel Biospecimen Banking

The CR-AZI Study will assess the immunomodulatory effects of Azithromycin for pediatric Critical Asthma.

Pediatric AsthmaCritical Illness

Johns Hopkins All Children's HospitalNCT06223828

Observational

Implementation of Asthma Community Home and School Management Program (Asthma CHAMPS)

The long-term goal is to implement an evidence-based asthma intervention based on the Center for Disease Control's recommended framework (EXHALE) within Baltim…

Asthma in Children

Johns Hopkins UniversityNCT05814510

Phase 4

A Randomized, Placebo-controlled, Parallel Group Study Designed to Assess the Change in Mucociliary Clearance After 12 Weeks of Treatment With Dupilumab in Patients With Moderate to Severe Asthma

Single center, randomized, placebo- controlled study to assess change in mucociliary clearance of moderate to severe asthma patients after treatment with dupil…

Sally E. Wenzel MDNCT04743791

~$10 – $7,500

Comparison of Microglial Activation in Severe Asthma and Healthy Controls

The goal of this clinical trial is to learn about how asthma influences brain function. The main questions it aims to answer are: * How airway inflammation in…

University of Wisconsin, MadisonNCT06299592

~$10 – $750

Observational

Mechanistic Study of Inspiratory Training in Childhood Asthma (MICA)

This is single-center cross-sectional mechanistic study in lean and obese children with moderate-severe asthma, followed by a randomized, SHAM-controlled trial…

Asthma in ChildrenObesityPediatric Obesity+1 more

Duke UniversityNCT05945355

Phase 1

Open-Label, Randomized, Single Dose, Parallel Group, Phase 1 Study in Healthy Volunteers to Evaluate the Relative Bioavailability of Two Formulations of GSK5784283 Administered by Subcutaneous Injection

The purpose of this study is to compare how two different formulations of the study medicine (GSK5784283) move through the body over time (pharmacokinetic \[PK…

GlaxoSmithKlineNCT07712393

~$10 – $7,500

Phase 2

A Phase 2 Randomized Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Three Doses of Frevecitinib (KN-002) in Patients With Severe Asthma

A Phase 2 Dose Ranging Study to Evaluate the Efficacy and Safety of Frevecitinib (KN-002) Over a 12-Week Treatment Period in Patients With Severe Asthma Not Co…

Severe Asthma

Kinaset Therapeutics IncNCT07532265

~$10 – $8,750

Phase 4

Giving Asthmatics Intramuscular Steroids for Preventing Return to the Emergency Department: A Randomized Control Trial

This study aims to compare the efficacy of a one-time IM dose of dexamethasone versus a 5-day course of prednisone in adult ED patients presenting with asthma …

Montefiore Medical CenterNCT07228052

A Biorepository of Multiple Allergic Diseases (MADREP) With Longitudinal Follow-up

Background: Allergic or sinus diseases can affect the skin, sinuses, airways, and other parts of the body. Examples include pollen and environmental allergies…

Allergy, Sinus Disorders, Atopic Diseases, Asthma, Allergic Rhinitis, Atopic Dermatitis, EoE, Drug a

National Institute of Allergy and Infectious Diseases (NIAID)NCT06732414

~$10 – $675

Phase 1

Anakinra Rescue Treatment for Moderate Asthma Attacks (ARTMA) Pilot Study

In this single center, interventional pilot study, 40 participants at high risk for future exacerbation will be randomized to anakinra (v. placebo control) tre…

Asthma (Diagnosis)Persistent AsthmaModerate Asthma Exacerbation

University of North Carolina, Chapel HillNCT07600190

Implementation of a Multilevel Program to Reduce Asthma Symptoms in Urban Preschoolers

Despite a strong evidence-base for the efficacy of multilevel programs in reducing asthma symptoms among low-income preschool minority children, gaps remain in…

Asthma in ChildrenImplementationPreschool Children