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Prospective Study of the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders

Background: Pyrimidine and purine metabolism disorders (DPPMs) affect how the body metabolizes chemicals called pyrimidines and purines. DPPMs can cause dysfu…

AMPD3, OMIM*102772, AMP Deaminase DeficiencyAK1, OMIM *103000, Adenylate Kinase DeficiencyAMPD1, OMIM *102770, Myopathy Due to Myoadenylate Deaminase Deficiency+25 more

Estimated

~$10 – $675

National Human Genome Research Institute (NHGRI)NCT06092346

Phase 1

A Pilot Study of Soursop Tea in Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML) or Multiple Myeloma (MM)

Purpose/Specific Aims The study will determine if there is a reduction in malignant cell burden when patients with relapsed and/or refractory acute myeloid le…

AML (Acute Myeloid Leukemia)Multiple Myeloma Refractory

Estimated

~$10 – $7,500

Roger StrairNCT07771803

Phase 2

A Phase 2, Open-Label, Master Protocol Study to Evaluate Safety and Efficacy of Treatment Combinations With Telisotuzumab Adizutecan in Subjects With Pancreatobiliary Cancers (AndroMETa-118)

Cancer is a condition where cells in a specific part of the body grow and reproduce uncontrollably. The pancreas is a gland behind the stomach that produces a …

Pancreatobiliary CancersPancreatic Ductal Adenocarcinoma

Estimated

~$10 – $7,500

AbbVieNCT07769502

Detection of Colorectal Cancer or Advanced Neoplasia by Stool DNA in Lynch Syndrome: CORAL Study

This study collects blood and stool samples from patients with suspected or diagnosed Lynch syndrome to evaluate a deoxyribonucleic acid (DNA) screening techni…

Colorectal CarcinomaLynch Syndrome

Estimated

~$10 – $750

Mayo ClinicNCT05410977

Phase 2

A Phase II, Open-label, Multicenter, Master Protocol to Evaluate the Safety and Efficacy of Novel Study Interventions and Combinations in Participants With Colorectal Cancer (CANTOR)

The main purpose of this study is to evaluate the safety and efficacy of novel study interventions and combinations in participants with Colorectal Cancer (CRC…

Metastatic Colorectal Cancer

Estimated

~$10 – $7,500

AstraZenecaNCT06792695

Microbiome Determinants of Adverse Effects of Stereotactic Radiosurgery

This prospective observational study will investigate the relationship between the gut microbiome and adverse effects following stereotactic radiosurgery (SRS)…

Adverse Radiation EffectsRadiation Necrosis

Estimated

~$10 – $750

University of ChicagoNCT07767981

Cor360: Clinician-Facing Broad-Spectrum Cardiac Phenotyping and Risk Assessment Using COR® Wearable ECG to Inform Outcomes-Oriented Care Pathways

Cor360 is an observational study evaluating whether extended wearable electrocardiogram (ECG) data can support broad-spectrum cardiac phenotyping and risk asse…

Cardiovascular DiseasesCardiovascular Diseases RiskCardiac Conduction System Disease+21 more

Estimated

~$10 – $1,050

Peerbridge Health, IncNCT07775976

Phase 1

A Phase 1/2A, Randomized Study of a T Follicular Helper (TFH)-Targeting Genetic Vaccine Strategy Designed to Induce Broad, Durable Immune Responses

The goal of this clinical trial is to test two investigational COVID-19 booster vaccines, called CoTend-s3BXBB and CoTend-BXBB, in healthy volunteers ages 40-6…

COVID-19SARS-CoV-2 Infection

Artidis Nanomechanical Signature Profiling of Pancreatic Cancer Specimens (ANoPs)

The goal of this clinical study is to evaluate whether the NEO-Match® test, based on ARTIDIS nanomechanical profiling technology, can help predict treatment ou…

Pancreatic CancerPancreatic NeoplasmsPancreatic Ductal Adenocarcinoma (PDAC)+1 more

Estimated

~$10 – $8,750

ARTIDIS AGNCT07542041

Observational

Transanal Irrigation for the Management of Early Low Anterior Resection Syndrome (LARS): A Pilot Randomized Controlled Trial

Transanal irrigation (TAI) has shown to improve fecal incontinence and increase quality of life in patients with low anterior resection syndrome (LARS). This t…

Colorectal CancerLow Anterior Resection Syndrome

Estimated

~$10 – $6,250

Case Comprehensive Cancer CenterNCT07219745

Phase 4

Pilot Exploration of Platelet Characterization of Platelet Rich Plasma Created by Two Different Systems

The investigators would like to study the differences in the quality of Platelet Rich Plasma (PRP) between two different machines in those with knee osteoarthr…

Knee OsteoarthristisCartilage DamagePlatelet Rich Plasma+1 more

Estimated

~$10 – $5,625

University of California, San FranciscoNCT07491367

Phase 2

A Phase 2 Study of the Safety and Efficacy of Neoadjuvant Botensilimab in Combination With Balstilimab in the Treatment of Microsatellite Stable / Mismatch Repair Proficient Early Rectal Cancer (RECTIFY-1)

This is a multi-site, prospective, non-randomized phase 2 study evaluating neoadjuvant botensilimab in combination with balstilimab for patients with microsate…

Early Rectal CancerStage I Rectal CancerMicrosatellite Stable Rectal Carcinoma

Estimated

~$10 – $7,500

Dana-Farber Cancer InstituteNCT07735624