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4,634 recruiting studies matching your filters

A Phase I Pharmacokinetic and Safety Assessment of Oral Letermovir in Infants With Symptomatic Congenital Cytomegalovirus Disease

This is a Phase 1 single-arm open-label study of letermovir in neonates with symptomatic congenital Cytomegalovirus (CMV) disease. There will be two groups enr…

Congenital Cytomegalovirus Infection

Estimated

~$10 – $5,625

National Institute of Allergy and Infectious Diseases (NIAID)NCT06118515

Phase 1

Nano-SMART: An Adaptive Phase I-II Trial of AGuIX Gadolinium-based Nanoparticles With Stereotactic Magnetic Resonance-guided Adaptive Radiation Therapy for Centrally Located Lung Tumors and Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma

This research study is being done to help determine the safety and efficacy of gadolinium based nanoparticle, Activation and Guidance of Irradiation X (AGuIX),…

Non-small Cell Lung CancerAdvanced Pancreatic AdenocarcinomaUnresectable Pancreatic Cancer+1 more

Estimated

~$10 – $7,500

Dana-Farber Cancer InstituteNCT04789486

Observational

Optimizing Psychological Health and Preventing Clinical Problems: Testing the Effectiveness of an Evidence-Based Toolkit for Integrated Operational Support

Sub-clinical behavioral health services in the military are performed by BH technicians, who receive minimal training. Due to this, embedding more technicians …

Depression, AnxietyGriefLeadership+1 more

Estimated

~$10 – $6,250

New York UniversityNCT06981598

Observational

Characterization of Human Olfactory Amygdala Subregions

We aim to better understand the functions of the subregions of the human amygdala that receive direct projections from the olfactory bulb

Changes in Olfactory Behavior Across Different Contexts Associated With Different Amygdala Subregions

Estimated

~$10 – $6,250

Northwestern UniversityNCT07074574

Phase 1

A Phase 1/2, Open-label Study of PD-1 Knockout Tumor-infiltrating Lymphocytes (IOV-4001) in Participants With Unresectable or Metastatic Melanoma or Stage III or IV Non-small-cell Lung Cancer

This is a study to investigate the efficacy and safety of an infusion of IOV-4001 in adult participants with unresectable or metastatic melanoma or advanced no…

Unresectable MelanomaMetastatic MelanomaStage III Non-small Cell Lung Cancer+1 more

Estimated

~$10 – $8,750

Iovance Biotherapeutics, Inc.NCT05361174

GLP-1 Medication & Behavioral Health on Weight and Metabolic Outcomes: FLOURISH (Functional Longitudinal Outcomes Under Intentional Small Habits) & THRIVE (Trajectories of Health, Resilience & Integrated Vitality Evaluation) Cohort Study

This research program includes two coordinated prospective studies (FLOURISH and THRIVE) evaluating the real-world effectiveness of Noom's digital health progr…

Obesity & OverweightWeight LossPreventative Health+2 more

Feasibility and Safety of Single-Port Robotic-Assisted DIEP Flap Harvest for Breast Reconstruction: A Prospective Evaluation

The primary aim of this study is to evaluate the feasibility of single-port robotic surgery for DIEP flap breast reconstruction. The investigators will also in…

DIEP Flap Breast Reconstruction

Estimated

~$10 – $6,250

Vanderbilt University Medical CenterNCT07222514

Phase 3

An Interventional Study of Letermovir for Secondary Prophylaxis After Treatment of Cytomegalovirus Infection in High Risk (D+/R-) Kidney and Kidney/Pancreas Transplant Recipients

This study is designed to assess how effective letermovir is in preventing recurrence of cytomegalovirus (CMV) infection in adult kidney or kidney/pancreas tra…

Cytomegalovirus InfectionsKidney Transplant InfectionPancreas Transplant

Estimated

~$10 – $6,250

University of Wisconsin, MadisonNCT06407232

Observational

Impact of Postoperative Regular Diet on Colorectal Outcomes and Patient Quality of Life

The goal of this pilot study is to assess the safety and feasibility of regular diet after surgical removal of the colon. The study will enroll patients preope…

ColorectalDiet HabitsSurgery+1 more

Estimated

~$10 – $6,250

Weill Medical College of Cornell UniversityNCT07540845

Phase 3

Robotic Opioid-free Prostatectomy Enhanced Strategy (ROPES): Implementation of an Opioid-free Multimodal Analgesia Discharge Pathway

This prospective, interventional, open-label, phase 3 randomized study evaluates a multimodal analgesia discharge pathway to reduce automatic opioid prescribin…

Opioid Consumption, PostoperativeMultimodal AnalgesiaRobotic Assisted Laparoscopic Surgery+2 more

Estimated

~$10 – $6,250

Brigham and Women's HospitalNCT07427043

Phase 2

Trial of Topical Fluorometholone as Adjunctive Therapy for Bacterial Corneal Ulcers

The investigators seek to determine whether adjunctive topical fluorometholone (FML) improves best-corrected visual acuity (BCVA) at 3 months in patients with …

Keratitis BacterialCorneal Ulcer (Diagnosis)

Estimated

~$10 – $7,500

Vishal JhanjiNCT07308938

Phase 1

A Pilot Study of Zimberelimab and Quemliclustat Combination With Chemotherapy in Patients With Borderline Resectable and Locally Advanced Pancreatic Adenocarcinoma

This phase I/II study tests how well zimberelimab and quemliclustat work in combination with chemotherapy (mFOLFIRINOX) in treating patients pancreatic adenoca…

Borderline Resectable Pancreatic AdenocarcinomaLocally Advanced Pancreatic Ductal Adenocarcinoma

Estimated

~$10 – $6,250

Jonsson Comprehensive Cancer CenterNCT05688215