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A Master Protocol for a Randomized, Controlled, Clinical Trial of Multiple Pharmacologic Agents in Adult Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease Who Are at Increased Risk of Developing Major Adverse Liver Outcomes

The main purpose of the SYNERGY-OUTCOMES study is to find out whether retatrutide and tirzepatide can prevent major adverse liver outcomes (MALO) in people wit…

Metabolic Dysfunction-Associated Steatotic Liver Disease

Estimated

~$10 – $7,500

Eli Lilly and CompanyNCT07165028

Phase 2

A Phase 2 Single Arm Trial of Stereotactic Body Radiation Therapy Followed by Dual Immune Checkpoint Inhibition for Patients With Metastatic Pancreatic Ductal Adenocarcinoma - The Miami "EMPIRE" Trial - Eradication of Metastatic Pancreatic Cancer With Immuno-Radiation

The purpose of this study is to assess if radiation therapy (which uses high-energy radiation to damage or destroy cancer cells) combined with immune checkpoin…

Metastatic Pancreatic Ductal AdenocarcinomaMetastatic Pancreatic Cancer

Estimated

~$10 – $7,500

Benjamin SpielerNCT06843551

A Multicenter, Prospective Blood Collection Study in a Kidney Transplant Population

The purpose of this research is to collect blood samples and data from kidney transplant patients. The samples and data will be used for research and developme…

Kidney DiseaseKidney TransplantTransplant Recipient+3 more

Estimated

~$10 – $1,050

Devyser Inc.NCT07006831

Phase 3

A Phase 3, Two-Stage, Randomized, Multicenter, Open-Label Study Comparing Mezigdomide (CC-92480), Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Subjects With Relapsed or Refractory Multiple Myeloma (RRMM): SUCCESSOR-1

The purpose of this study is to compare the efficacy and safety of mezigdomide (CC-92480), bortezomib and dexamethasone (MeziVd) versus pomalidomide, bortezomi…

Relapsed or Refractory Multiple Myeloma

Estimated

~$10 – $7,500

CelgeneNCT05519085

Psychotherapy for Irritability in Youth: Comparing Active Treatment to Non-Active Psychoeducation Supportive Psychotherapy

Background: Irritability is defined as proneness to anger that may impair a person's ability to function. It is a common reason for why some children need men…

IrritabilityDisruptive Mood Dysregulation DisorderOppositional Defiant Disorder+1 more

Estimated

~$10 – $675

National Institute of Mental Health (NIMH)NCT07640802

Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs

The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of childre…

Coronavirus Infection (COVID-19)Pulmonary Arterial HypertensionUrinary Tract Infections in Children+22 more

Estimated

~$10 – $750

Duke UniversityNCT04278404

Phase 1

Phase 1/1b First-in-human Study of Autologous Chimeric Engulfment Receptor T-Cell CER-1236 in Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, and Myelofibrosis (CertainT-1)

This is a ﬁrst in human, multi center, open label, phase 1/1b study to evaluate the safety and preliminary efﬁcacy of CER-1236 in patients with relapsed/refrac…

AMLAcute Myeloid LeukemiaRefractory Acute Myeloid Leukemia

Estimated

~$10 – $8,750

CERo Therapeutics Holdings, Inc.NCT06834282

Vascular Disease Discovery Protocol

Background: Some genetic diseases put increase the risk of heart and blood diseases, which are the number one cause of death and disability in the U.S. Resear…

Vascular DysfunctionGenetic MutationsGenetic Predisposition

Estimated

~$10 – $675

National Heart, Lung, and Blood Institute (NHLBI)NCT03538639

Phase 2

Phase II Study Assessing the Effect of BK Specific CTL Lines Generated by Ex Vivo Expansion in Patients With BK Virus Infection and JC Virus Infection

This phase II trial studies how well donor cytotoxic T lymphocytes work in treating patients with malignancies with BK and/or JC virus. Cytotoxic T lymphocytes…

Acquired Immunodeficiency SyndromeBK Virus InfectionHuman Immunodeficiency Virus+5 more

Estimated

~$10 – $6,250

M.D. Anderson Cancer CenterNCT02479698

Women's Ischemia Syndrome Evaluation (WISE) - Coronary Microvascular Dysfunction (CMD) and Heart Failure With Preserved Ejection Fraction (HFpEF)

The Women's Ischemia Study Evaluation (WISE), a cohort study of over 1000 women, has made many contributions to the understanding of cardiovascular disease. A …

Microvascular Coronary DysfunctionCardiovascular Disease

Estimated

~$10 – $750

Cedars-Sinai Medical CenterNCT02582021

Phase 2

A Phase II Study of Inotuzumab Ozogamicin Followed by Blinatumomab for Ph-Negative, CD22-Positive B-Lineage Acute Lymphoblastic Leukemia in Newly Diagnosed Older Adults or Adults With Relapsed or Refractory Disease

This phase II trial studies how well inotuzumab ozogamicin and blinatumomab with or without ponatinib work in treating patients with CD22-positive B-lineage ac…

B Acute Lymphoblastic Leukemia, Philadelphia Chromosome NegativeRecurrent B Acute Lymphoblastic LeukemiaRefractory B Acute Lymphoblastic Leukemia

Estimated

~$10 – $5,625

National Cancer Institute (NCI)NCT03739814

Phase 2

Phase II Haploidentical Hematopoietic Stem Cell Transplantation for Participants With Germline RUNX1 Associated Hematologic Malignancies

Background: Some blood cancers can be caused by germline variants (changes) in a person s RUNX1 gene. Germline variants are genetic inherited changes a person…

Core Binding Factor Alpha SubunitsHematologic NeoplasmsLeukemia+1 more

Estimated

~$10 – $5,625

National Cancer Institute (NCI)NCT07524530