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Oral Fluid Testing to Assess Cannabis Non-Use in Remote Clinical Trials
The purpose of this study is to identify and evaluate oral fluid testing as a biologic measure of cannabis use days that can be assessed remotely. The research…
The Neural Underpinnings of Depression and Cannabis Use in Young People Living With HIV
To elucidate mechanisms of substance use disorders (SUD) and comorbid mental illnesses in people living with HIV (PLWH), the study team seeks to investigate re…
Neuroimaging of Instrumental Learning Networks in Adolescent Cannabis Use Treatment
This study is testing whether brain activity related to learning can help predict how well teens respond to a treatment program designed to reduce cannabis use…
Hemp-derived Cannabidiol for the Treatment of Cannabis Use Disorder: A Double-blind Placebo-controlled Randomized Trial
This study is a placebo-controlled randomized trial comparing the effects of hemp-derived cannabidiol (CBD) with and without Delta-9-tetrahydrocannabinol (THC)…
AMP-C: A Digital Therapeutic for Reward Dysfunction in Co-Occurring Depression and Cannabis Use
The purpose of this study is to examine the feasibility, acceptability, and preliminary efficacy of a digital intervention for co-occurring cannabis use and de…
Transcranial Magnetic Stimulation for Adolescents and Young Adults With Cannabis Use Disorder
This pilot study will investigate the potential of repetitive transcranial magnetic stimulation (rTMS) to strengthen a neural circuit critical for maintaining …
Prospective Changes in Patient-reported and Objective Functioning Following Reduction of Cannabis Use
This study evaluates the effects of cannabis use reduction among adults diagnosed with cannabis use disorder (CUD). Participants will undergo an 8-week interve…
Synaptic Density in Psychiatric Disorders Using SV2A Receptor PET Imaging With [11C]APP311
The aim of this study is to evaluate a new SV2A tracer, \[11C\]APP311, in healthy aging and neuropsychiatric disorders including psychotic disorders and cannab…
Pilot Study of Psilocybin-assisted Treatment for Cannabis Use Disorder
This pilot study will evaluate the therapeutic potential of psilocybin in people with Cannabis Use Disorder (CUD). This study will examine the impact of psiloc…
Emotional Brain Training for Addiction Medicine Treatment - A Pilot Study
The goal of this clinical trial is to determine whether Emotional Brain Training (EBT), a behavioral modification method, can help manage stress and health pro…
Sex Differences in Neurobehavioral Response to Acute THC in Adults With Cannabis Use Disorder
This study investigates sex differences in reward processing following acute THC administration in adults with cannabis use disorder (CUD). Using multimodal ne…
Experimental Manipulation of the Emotional Salience of Cannabis Use-Related Information in Regular Cannabis Users
The goal of this study is to test a causal neural mechanism of cannabis use-related problem recognition in individuals with severe cannabis use disorder using …