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79 recruiting studies matching your filters

Open Label Phase 1 and Target Validation Study of ONC206 in Children and Young Adults With Newly Diagnosed or Recurrent Diffuse Midline Glioma (DMG), and Other Recurrent Primary Malignant Central Nervous System (CNS) Tumors

This phase I trial studies the effects and best dose of ONC206 alone or in combination with radiation therapy in treating patients with diffuse midline gliomas…

Diffuse Midline Glioma (DMG)GlioblastomaRecurrent Ependymoma+5 more

Estimated

~$10 – $7,500

Sabine Mueller, MD, PhDNCT04732065

Phase 2

Phase 2 Study of Avapritinib in Patients With CKIT or PDGFRA Mutation-Positive Malignant Solid Tumors

This phase II trial studies the effect of avapritinib in treating malignant solid tumors that have a genetic change (mutation) in CKIT or PDGFRA and have sprea…

Anatomic Stage IV Breast Cancer AJCC v8Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8+26 more

Phase 1

A Phase I Study of MB-CART19.1 Cellular Therapy for Relapsed/Refractory Primary and Secondary Central Nervous System Lymphoma (CNSL) Using On- Site Manufacturing With the CliniMACS Prodigy Device

This study will test whether MB-CART19.1 is a safe and effective treatment for central nervous system lymphoma (CNSL). This study will test different doses of …

Primary Central Nervous System (CNS) LymphomaSecondary Central Nervous System Lymphoma

Estimated

~$10 – $6,250

Memorial Sloan Kettering Cancer CenterNCT07137494

Neurocognitive Outcomes After Whole Brain Radiation Therapy for Hematologic Malignancies

This study assesses neurocognitive outcomes after receiving radiation therapy to the brain (whole brain radiation therapy) in patients with blood cancers (hema…

Central Nervous System LymphomaHematopoietic and Lymphoid Cell NeoplasmLeukemia+3 more

Estimated

~$10 – $750

M.D. Anderson Cancer CenterNCT05011045

Somatic Mosaicism in Twins Discordant for Childhood Cancer: a Pilot Study

Somatic mosaicism in cancer associated genes is one potential explanation for discordance in childhood cancer that has not been fully explored to date. This pi…

Pediatric Central Nervous System TumorCentral Nervous System TumorDiscordant Twin+1 more

Estimated

~$10 – $1,125

Children's Oncology GroupNCT06054295

Long-term Follow-up Study of Patients Receiving CAR-T Cells

This protocol is designed as a long-term follow-up study of participants who will receive CAR-T cells as part of a clinical trial at the Medical College of Wis…

Chronic Lymphocytic LeukemiaLymphomas Non-Hodgkin's B-CellLymphoma, Small Lymphocytic+6 more

Estimated

~$10 – $750

Medical College of WisconsinNCT03375619

Phase 1

Acalabrutinib Maintenance Following Cellular Therapy for Large B-Cell Lymphoma Patients at Very High Risk for Relapse

This phase Ib/II trial studies the side effects and efficacy of maintenance acalabrutinib following cellular therapy in treating patients with large B-cell lym…

Diffuse Large B-Cell LymphomaHigh-grade B-cell LymphomaTransformed Lymphoma+1 more

Estimated

~$10 – $6,250

Jonsson Comprehensive Cancer CenterNCT05256641

Phase 1

A First-in-human Phase I Single-agent Dose-escalation, Food Effect and Dose Expansion Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms

The primary objective of this Phase 1, open-label, dose-escalation, and exploratory study is to evaluate the safety and tolerability profile (establish the max…

Central Nervous System NeoplasmsGlioblastomaGliosarcoma, Adult+20 more

Pilot Trial of Short Course Radiotherapy for Primary or Secondary CNS Malignancies

This is a single arm prospective pilot trial determining the safety of short-course radiation therapy in pediatric patients with incurable central nervous syst…

Central Nervous System Cancer

Estimated

~$10 – $6,250

Abramson Cancer Center at Penn MedicineNCT07147179

Phase 2

CD19-Directed Chimeric Antigen Receptor CD19 Redirected Autologous T Cells (CART19) for Orphan Indications of Pediatric B Cell Acute Lymphoblastic Leukemia (B ALL)

This is an open-label, four-cohort, phase 2 study to determine the efficacy of CART19 in pediatric and young adult patientswith hypodiploid (Cohort A) or t(17;…

Pediatric and Young Adult Patientswith Hypodiploid or t(17;19) B-ALLInfants With Very High Risk KMT2A B-ALLPatients With Central Nervous System Relapse Who Did Not Receive Cranial Radiation or Bone Marrow Transplantation

Estimated

~$10 – $7,500

Stephan Grupp MD PhDNCT04276870

Observational

Chronic Stimulation of the Motor Ventral Thalamus (VOP/VIM) for Motor Control in Humans

This study aims to recruit patients already implanted with Deep Brain Stimulation (DBS) for movement disorders to complete tasks assessing parameters of motor …

Traumatic Brain InjuryStrokeBrain Disease+4 more

Estimated

~$10 – $7,500

Jorge Gonzalez-MartinezNCT07056348

Phase 2

Zanubrutinib With Pemetrexed for the Treatment of Relapsed/Refractory Primary and Secondary CNS Lymphomas: A Phase II Trial With a Safety Lead-In

This study is being conducted to evaluate the safety and efficacy of the combination of pemetrexed and zanubrutinib (called induction therapy) followed by zanu…

Primary Central Nervous System LymphomaSecondary Central Nervous System LymphomaRelapsed Cancer+1 more

Estimated

~$10 – $7,500

Baptist Health South FloridaNCT05681195