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68 recruiting studies matching your filters

A Phase 1 Open-Label, Single-Dose, Parallel-Group Study of the Pharmacokinetics and Safety of VIR-2218 and VIR-3434 Monotherapy and Combination Therapy in Adult Participants With Hepatic Impairment

In this study, a single dose of VIR-2218 up to 200 mg SC or VIR-3434 at 300 mg SC monotherapy or a combination of VIR-2218 and VIR-3434 will be administered to…

Hepatic ImpairmentCirrhosis

Estimated

~$10 – $8,750

Vir Biotechnology, Inc.NCT05484206

Coordination of Rare Diseases at Sanford

CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, …

Rare DisordersUndiagnosed DisordersDisorders of Unknown Prevalence+340 more

Phase 1

A 12-Month, Open-Label Study Evaluating Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Siplizumab as Induction Therapy in Patients With Autoimmune Liver Diseases Undergoing Liver Transplantation (SET-SAIL)

There is a significant unmet need for safe and effective therapeutic approaches to prevent immune-mediated graft injury and its complications in liver transpla…

Autoimmune Liver DiseaseLiver Transplant DisorderAutoimmune Hepatitis+3 more

Estimated

~$10 – $7,500

Elizabeth C. VernaNCT06455280

Phase 2

Phase II Randomized Controlled Trial of Epigallocatechin Gallate for Hepatocellular Carcinoma Chemoprevention

This phase II trial tests epigallocatechin gallate (EGCG) for its efficacy and safety in preventing development of hepatocellular carcinoma (HCC) in patients w…

Cirrhosis, Liver

Estimated

~$10 – $6,250

University of Texas Southwestern Medical CenterNCT06015022

Observational

Transitional Care Program vs Standard of Care in Cirrhosis With Volume Overload: A Pilot Study

The goal of this clinical trial is to learn about an intensive monitoring plan (transitional care program) in patients with cirrhosis and excessive swelling th…

Cirrhosis, Liver

Estimated

~$10 – $6,250

Milton S. Hershey Medical CenterNCT06174272

A Resource of Blood and Other Biospecimens of Patients With Cholestatic Liver Disease and Unaffected Individuals

This study is a biobank of specimens and clinical data for use in current and future research to better understand the cholestatic liver diseases primary bilia…

Primary Sclerosing CholangitisPrimary Biliary CirrhosisCholangiocarcinoma+1 more

Estimated

~$10 – $750

Mayo ClinicNCT03445585

Phase 2

Multi-center Double Blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of Long-term Atorvastatin (20 mg/Day) v. Placebo on HCC Risk in Individuals With Advanced Liver Fibrosis

Prospective randomized, multi-center, double blind placebo-controlled trial to assess the chemopreventive impact of atorvastatin (20 mg oral) vs placebo in up …

Liver FibrosesCirrhosis

Estimated

~$10 – $7,500

Raymond ChungNCT05028829

Phase 3

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of Namodenoson in the Treatment of Advanced Hepatocellular Carcinoma in Patients With Child-Pugh Class B7 Cirrhosis

This is a clinical trial in patients with advanced hepatocellular carcinoma (HCC) and Child-Pugh Class B7 (CPB7) cirrhosis whose disease has progressed on at l…

Hepatocellular CarcinomaCirrhosis

Estimated

~$10 – $8,750

Can-Fite BioPharmaNCT05201404

Phase 2

A Multi-center, Randomized, Placebo-controlled Trial of S-Adenosylmethionine (SAMe) in Patients With Alcoholic Cirrhosis

The proposed of this randomized, double blinded, placebo-controlled study is to assess the effect of SAMe compared to placebo in patients with alcoholic cirrho…

Alcoholic Cirrhosis

Estimated

~$10 – $6,250

Indiana UniversityNCT04250259

Development of 4D Flow MRI for Risk Stratification of Variceal Bleeding in Cirrhosis

The goal of this research is to validate novel non-invasive Magnetic resonance imaging (MRI) biomarkers to detect Gastroesophageal varices (GEV) in patients wi…

Cirrhosis, LiverGastroesophageal VaricesFontan Procedure

Estimated

~$10 – $750

University of Wisconsin, MadisonNCT04867954

Changes in Glucose Tolerance in Patients With Cirrhosis Peri-Liver Transplant

The goal of this observational study is to establish risk factors for post-transplant in adult individuals with cirrhosis without diabetes undergoing liver tra…

Cirrhosis, LiverDiabetes Mellitus RiskTransplant; Failure, Liver+1 more

Estimated

~$10 – $750

University of ChicagoNCT06950788

Phase 1

The Microbiota Augmentation to Reestablish Commensal Organisms (MARCO) Trial

The Microbiota Augmentation to Reestablish Commensal Organisms (MARCO) trial is a single center prospective adaptive phase 1b clinical trial in patients who ar…

Liver DiseasesLiver FailureCirrhosis, Liver

Estimated

~$10 – $6,250

University of ChicagoNCT06871111