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University of NebraskaNCT06184945

Sleep DeprivationCritical IllnessSleep-Wake Disorders+3 more

Comparing Two Multicomponent ICU Bundles To Promote Sleep and Reduce Delirium in Critically Ill Adults

SHANTI-ICU compares the effectiveness of two evidence-based multicomponent ICU sleep promotion bundles on delirium and patient-reported sleep quality in critic…

University of California, San DiegoNCT07840560

DysphagiaCritical Illness

Optimizing Dysphagia Treatment Delivery in Acute Care: A Hybrid Efficacy Implementation Trial

This research study is investigating the efficacy and implementation of expiratory muscle strength training (EMST), standard of care dysphagia treatment, and i…

Vanderbilt University Medical CenterNCT07736105

Critical IllnessIntensive Care Medicine

VoiceLove: An App-Based COMMunication Tool Designed to Address DeliriUm and Improve Family ENgagement and PatIent/Family SatisfaCtion in CriticAlly Ill PaTiEnts (COMMUNICATE)

VoiceLove is a phone application allowing family and patients to share information in a secure platform. This project will compare the VoiceLove app to usual c…

Vanderbilt University Medical CenterNCT06923462

GlucoseMetabolismIsotope Labeling+4 more

Tracing Of Real-time glu13Cose Metabolism in Human Immune Cells - Intensive Care Unit

The purpose of this study is to understand how cells of the immune system use the common sugar glucose during critical illness. Investigators will intravenousl…

Vanderbilt University Medical CenterNCT07811180

Decision MakingNeonatal Critical IllnessPediatric Critical Illness

Building Relationship, Improving Dialogue, and Growing Empathy (BRIDGE): An Intervention to Support Decision Making for Critically Ill Children

Parents of young children in the intensive care unit may be faced with decisions about their child's care. The Building Relationship, Improving Dialogue, and G…

Duke UniversityNCT07390773

SepsisDeterioration, ClinicalCritical Illness+1 more

CCAT Hospital-Onset Sepsis Systematic Detection and Structured Interventions

Sepsis is a life-threatening reaction to an infection. It can begin while a person is already in the hospital for some other reason. Sepsis that starts in the …

Patricks LyonsNCT07804251

~$10 – $7,500

Phase 4

Fluorescent Probe for Assessment of Renal Elimination

Accurate measures of kidney function is important for precision dosing of many medications. The current methods of determining kidney function largely hinge on…

Augmented Renal ClearanceCritical Illness

Critical IllnessDepressive Symptoms

~$10 – $7,500

Aaron CookNCT07643467

Phase 2

Ketamine In Depression - Intensive Care Unit Trial (KID-ICU): A Phase II Randomized, Double-Blind, Placebo-Controlled Multicenter Study of Ketamine Infusion for Depressive Symptoms in Intensive Care Unit Patients

Depressive symptoms are common among patients admitted to the intensive care unit (ICU) and may adversely affect recovery, participation in care, treatment adh…

Hospital Italiano de Buenos AiresNCT07639359

Transcranial Doppler Assessment of Cerebral Autoregulation and Blood Flow Velocity Patterns in Critically Ill Children: A Prospective Observational Study

This study uses a non-invasive (external) ultrasound test called Transcranial Doppler (TCD) to measure how blood flows through the major arteries of the brain …

Critical IllnessPediatric Critical IllnessRespiratory Failure+2 more

University of Wisconsin, MadisonNCT07613918

~$10 – $750

Phase 2

Exogenous Ketone Ester Supplementation in ICU Delirium (KETONES ICU)

Delirium is a common syndrome in intensive care unit (ICU) patients. Those experiencing delirium may suddenly feel confused, have trouble thinking clearly, str…

ICU DeliriumCritical Illness

Vanderbilt University Medical CenterNCT07364162

ChildIntensive Care Unit Acquired WeaknessCritical Illness+1 more

Clinical Effectiveness of the "PICU Up!" Multifaceted Early Mobility Intervention for Critically Ill Children: A Pragmatic, Stepped-wedge Trial

While mortality in U.S. pediatric intensive care units (PICUs) is improving, surviving children frequently develop persistent physical, cognitive, and psycholo…