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Sleep and Circadian Rhythm Biomarkers of Postoperative Delirium
The goal of this prospective cohort study is to assess potential differences in sleep biomarkers in older adult patients undergoing major orthopedic surgery. T…
HEARS Neuropsychiatric Symptoms & Hearing Loss: Addressing Hearing Loss as a Common Unmet Contributor of Neuropsychiatric Symptoms
This randomized controlled trial study aims to evaluate a revised hearing care intervention for older adults with Alzheimer's Disease and Related Dementias (AD…
Digital Detection of Dementia (D Cubed) Studies: D3
The specific aim of the pragmatic trial is to evaluate the practical utility and effect of the PDM, the QDRS, and the combined approach (PDM + QDRS) in improvi…
Modifiable Variables in Parkinsonism (MVP) [Formerly CAM Care in PD]
We are trying to identify factors associated with improved quality of life and fewer PD symptoms. We are attempting to identify practices, beliefs, and therapi…
PET Imaging Evaluation of [11C]SY08
The overall goal of the proposed research is to evaluate the use of \[11C\]SY08 as a PET radiotracer for aggregated alpha synuclein (αS) in individuals with Pa…
Cognitive Training to Reduce Incidence of Cognitive Impairment in Older Adults
Dementia is the most expensive medical condition in the US and increases in prevalence with age. More than 5 million Americans have Alzheimer's disease, the mo…
Characterization of Familial Myopathy and Paget Disease of Bone
The investigators are researching families with inherited inclusion body myopathy (IBM) and/or Paget disease of bone (PDB) and/or dementia (FTD) which is also …
Mechanistic Study of the "Let's Talk Tech" Dyadic Behavioral Intervention to Support Decision Making About Technology Use
The goal of this research is to educate people about different technologies to support care at home when someone is experiencing memory difficulties. "Let's Ta…
Sequential Accelerated ITBS / Remote tDCS for Treatment of Neuropsychiatric Symptoms in Alzheimer's Disease: A Pilot Study
The goal of this pilot study is to test a combination of two non-invasive brain stimulation methods, called iTBS (intermittent theta burst stimulation) and tDC…
ACTIVE MIND: An Adaptive Clinical Trial of Cognitive Training to Improve Function and Delay Dementia
Older adults at risk for dementia show a variety of cognitive deficits, which can be ameliorated by different cognitive training (CT) exercises. The best combi…
Persons With Dementia and Their Extended Family Caregivers: Service Use, Barriers and Needs
Immediate family members shoulder the majority of care responsibilities for persons living with dementia. However, due to various societal changes, elder care …
Genetic Studies of Early-onset Dementia
The aim of this study is to identify genetic factors that contribute to risk and progression of early-onset dementia (loss of memory function before the age of…